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Introduction: To expand access to naloxone, the state of Illinois implemented a standing order allowing registered pharmacies to dispense the drug without an individual prescription. To participate under the standing order, pharmacies were required to opt in through a formal registration process. In our study we aimed to evaluate the availability and price of naloxone at registered pharmacies.
Methods: This was a prospective, de-identified, cross-sectional telephone survey. Trained interviewers posed as potential customers and used a standardized script to determine the availability of naloxone between February-December, 2019. The primary outcome was defined as a pharmacy indicating it carried naloxone, currently had naloxone in stock, and was able to dispense it without an individual prescription.
Results: Of 948 registered pharmacies, 886 (93.5%) were successfully contacted. Of those, 792 (83.4%) carried naloxone, 659 (74.4%) had naloxone in stock, and 472 (53.3%) allowed purchase without a prescription. Naloxone nasal spray (86.4%) was the formulation most commonly stocked. Chain pharmacies were more likely to carry naloxone (adjusted odds ratio [aOR] 3.16, 95% confidence interval [CI] 1.97-5.01, < 0.01) and have naloxone in stock (aOR 2.72, 95% CI 1.76-4.20, < 0.01), but no more likely to dispense it without a prescription. Pharmacies in higher population areas (aOR 0.99, 95% CI 0.99-0.99, < 0.05) and rural areas adjacent to metropolitan areas (aOR 0.5, 95% CI 025-0.98, < 0.05) were less likely to have naloxone available without a prescription. Associations of naloxone availability based on other urbanicity designations, overdose count, and overdose rate were not significant.
Conclusion: Among pharmacies in Illinois that formally registered to dispense naloxone without a prescription, the availability of naloxone remains limited. Additional interventions may be needed to maximize the potential impact of a statewide standing order.
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http://dx.doi.org/10.5811/westjem.17979 | DOI Listing |
J Egypt Natl Canc Inst
September 2025
National Cancer Institute of Cairo University, Giza, Egypt.
Objectives: To balance the extended functional urinary voiding and morbidity outcomes amid Ileal W and Y-shaped contrasted to spherical ileocoecal (IC) orthotopic bladders subsequent prostate-sparing radical cystectomy (PRC) versus standard radical cystoprostatectomy (RC).
Material And Methods: Two hundred eight male bladder cancer patients were grouped into 98 RC followed by 43-W, 31-Y, and 23-IC in comparison to 110 PRC followed by 35-W, 37-Y, and 38-IC. The functional voiding outcomes were determined by detailed patients' interview and urodynamic studies (UDS).
Ultramicroscopy
August 2025
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304W. Green Street, Urbana 61801, IL, USA; Materials Research Laboratory, University of Illinois at Urbana-Champaign, 104 South Goodwin Avenue, Urbana 61801, IL, USA. Electronic address:
Complex face-centered-cubic (FCC) alloys frequently display chemical short-range ordering (CSRO), which can be detected through the analysis of diffuse scattering. However, the interpretation of diffuse scattering is complicated by the presence of defects and thermal diffuse scattering, making it extremely challenging to distinguish CSRO using conventional scattering techniques. This complexity has sparked intense debates regarding the origin of specific diffuse-scattering signals, such as those observed at 1/3{422} and 1/2{311} positions.
View Article and Find Full Text PDFRev Peru Med Exp Salud Publica
August 2025
Universidad Peruana Cayetano Heredia, Laboratorio de Genómica Microbiana, Lima, Perú.
Background: Motivation for the study. To contribute to the genomic surveillance of UPEC in clinical samples from Latin America, in response to the growing public health problem represented by UTIs and their resistance to antimicrobials. Main findings.
View Article and Find Full Text PDFJ Phys Chem Lett
September 2025
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Heterogeneous ice nucleation, triggered by surfaces, profoundly impacts climate systems, biological processes, and technological applications. Classical nucleation theory (CNT) predicts that with curvature radii decreasing within 1 order of magnitude of the critical nucleus radius, convex surfaces should suppress nucleation and concave surfaces should promote nucleation; however, such regularity has not been observed explicitly in experiments, and there are even conflicting results. Here, we resolve this long-standing controversy by providing the first experimental evidence about the bidirectional regulation of ice nucleation from both liquid and vapor phases through precisely engineered convex (nanosphere) and concave (nanopore) surfaces.
View Article and Find Full Text PDFMath Biosci Eng
June 2025
Key Laboratory of Digital Control and System Engineering (DCSELab), Faculty of Mechanical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam.
Historically, the world has endured numerous respiratory pandemics, with the recent COVID-19 outbreak underscoring the significant importance of respiratory equipment and mechanical ventilators being no exception. Despite long-standing efforts in control and modeling system research, mechanical ventilators, especially the air generation unit, remain a significant challenge due to various factors and uncertainties (e.g.
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