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Twin reversed arterial perfusion (TRAP) sequence carries a high mortality risk to the "pump twin." Management involves disrupting blood flow to the acardiac mass. In this case, the pregnant patient presented at 20 weeks 6 days with Stage IIb TRAP Sequence and underwent percutaneous ultrasound-guided microwave ablation (MWA) of the acardiac mass at 21 weeks 0 days. The probe traversed the thorax of the acardiac mass and ablated the confluence of the umbilical vessels. A healthy child was delivered at 33 weeks 5 days gestation. This report demonstrates the utility of MWA in TRAP sequence and describes a novel approach.
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http://dx.doi.org/10.1002/jcu.23754 | DOI Listing |
Rev Sci Instrum
September 2025
Joint Quantum Institute, University of Maryland and National Institute of Standards and Technology, College Park, Maryland 20742, USA.
We describe an apparatus that efficiently produces 23Na Bose-Einstein condensates (BECs) in a hybrid trap that combines a quadrupole magnetic field with a far-detuned optical dipole trap. Using a Bayesian optimization framework, we systematically optimize all BEC production parameters in modest-sized batches of highly correlated parameters. Furthermore, we introduce a Lagrange multiplier-based technique to optimize the duration of different evaporation stages constrained to have a fixed total duration; this enables the progressive creation of increasingly rapid experimental sequences that still generate high-quality BECs.
View Article and Find Full Text PDFInt Immunopharmacol
September 2025
Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China; Department of Pharmacology, School of Basic Medical Sciences, Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China; State Key Laboratory for
Tacrolimus is widely used to prevent post-transplant acute kidney injury (AKI) but causes severe toxicities (e.g., nephrotoxicity, hyperglycemia).
View Article and Find Full Text PDFBiochem Pharmacol
September 2025
Section on Molecular Neuroscience, NIMH-IRP, Bethesda, MD, USA. Electronic address:
The PACAP receptor PAC1 is a G-coupled family B1 GPCR for which the highest-affinity endogenous peptide ligands are the pituitary adenylate cyclase-activating peptides PACAP38 and PACAP27, and whose most abundant endogenous ligand is PACAP38. PACAP action at PAC1 is implicated in neuropsychiatric disorders, atherosclerosis, pain chronification, and protection from neurodegeneration and ischemia. As PACAP also interacts with two related receptors, VPAC1 and VPAC2, highly selective ligands, both agonists and antagonists, for PAC1 have been sought.
View Article and Find Full Text PDFParallelization has revolutionized computing and DNA sequencing but remains largely unexploited in mass spectrometry (MS), which typically analyzes ions sequentially. We introduce a nature-inspired ion trap (MultiQ-IT) that enables massively parallel MS. The device comprises a cubic array of small quadrupoles forming multiple ion entry and exit ports, allowing >10⁹ ions to be confined and manipulated simultaneously.
View Article and Find Full Text PDFInt Dent J
September 2025
Shenzhen Clinical College of Stomatology, School of Stomatology, Southern Medical University, Shenzhen, China; Shenzhen Stomatology Hospital (Pingshan) of Southern Medical University, Shenzhen, China; Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electro
Background: Pulpitis is an oral disease primarily triggered by microbial infections. Current therapeutic strategies lack specific agents targeting the underlying pathogenic mechanisms. Non-coding RNAs (ncRNAs) and their competitive endogenous RNA (ceRNA) networks have emerged as critical regulators of diverse biological processes, offering novel insights into the pathogenesis of pulpitis and the identification of potential therapeutic targets.
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