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Purpose Of Review: To present current evidence in long-term (> 5 years) results after endoscopic sinus surgery (ESS) focusing on Patients Reported Outcome Measures (PROMs) and other sinonasal outcomes while assessing the role of ESS in the treatment of CRSwNP, and identifying outcomes which affect the results of ESS and defining recommendations for future studies.
Recent Findings: Long-term results of ESS in CRSwNP can be branched in PROMs and other objective measurements. Despite the heterogeneity of reported outcomes make it difficult to perform comparisons and meta-analysis, ESS improves PROMs, including symptoms, QOL and olfaction. Objectives outcomes such as NPS, LMS, type of surgery, or recurrence and revision surgery don't have a clear role in long-term results. Clustering patients suggest asthma, N-ERD, allergy, eosinophil count and IL-5 could have a role in predicting recurrence and severe disease. Long-term studies of CRSwNP treated with ESS are scarce. There is a significant need to standardize the report of results. The use of tools as SNOT-22, NPS, validated smell tests, defined criteria for disease recurrence and control and ESS extension in a unified systematic way could allow better comparisons between treatments in the new era of biologics.
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http://dx.doi.org/10.1007/s11882-024-01154-w | DOI Listing |
Am J Case Rep
September 2025
Department of Otolaryngology - Head and Neck Surgery, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
BACKGROUND Pediatric sinonasal tumors are rare, accounting for about 4% of all pediatric head and neck neoplasms. Due to their nonspecific symptoms such as nasal obstruction, epistaxis, and facial pain, these tumors often present diagnostic challenges and lead to delays in managment. Early and accurate diagnosis is crucial to optimize clinical outcomes.
View Article and Find Full Text PDFClin Otolaryngol
September 2025
Department of Otolaryngology-Head and Neck Surgery, Galway University Hospital, Galway, Ireland.
Introduction: Radiomics offers the potential to predict oncological outcomes from pre-operative imaging, aiding in the identification of 'high risk' patients with sinonasal cancer who are at an increased risk of recurrence. This study aims to comprehensively review the current literature on the role of radiomics as a predictor of disease recurrence in sinonasal squamous cell carcinoma.
Methods: A systematic search was conducted in Medline, EMBASE and Web of Science databases.
Prev Nutr Food Sci
August 2025
Department of Anatomy, Chonnam National University Medical School, Jeonnam 58128, Korea.
Sinonasal squamous cell carcinoma (SNSCC) is a rare, aggressive malignancy with poor clinical outcomes. Metabolic syndrome components, including obesity-associated hyperleptinemia, may promote tumor progression. Leptin is an adipokine that is elevated in obesity and activates oncogenic pathways that drive cancer cell proliferation.
View Article and Find Full Text PDFVestn Otorinolaringol
September 2025
Botkin Moscow Multidisciplinary Scientific and Clinical Center, Moscow, Russia.
Unlabelled: Inverted papilloma (IP) is a sinonasal epithelial tumor that originates from Schneiderian membrane. A number of cellular factors associated with angiogenesis are involved in growth of IP, and causes an increased bleeding of the tumor. The main treatment is surgical removal of sinonasal papilloma.
View Article and Find Full Text PDFClin Otolaryngol
September 2025
Aurelius Hospital Nilai, Nilai, Negeri Sembilan, Malaysia.
Objectives: The expression and functionality of bitter taste receptors (T2Rs) in the sinonasal mucosa have been linked to variations in chronic rhinosinusitis (CRS) severity and susceptibility, suggesting a potential therapeutic target for managing this chronic condition. This study is an initial proof-of-concept study to explore the potential of nasal bitter taste testing as a screening tool for CRS, aiming at developing a screening method to detect the bitter taste receptor in the nose and its sensitivity between healthy individuals and those with CRS using available bitter ligands; therefore, coming up with a suitable titration of this ligand for future use.
Methods: A cross-sectional study of 84 adults (42 with CRS and 42 healthy controls) evaluated nasal glucose levels and phenylthiocarbamide (PTC) taste sensitivity.