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Article Abstract
This paper determines the polymorphism distribution of the gene in 350 patients and provides medication recommendations for osteoporosis based on detection results. Chi-square tests compared genotype and allele frequencies with other populations. Genotype frequencies were 91.66 bb, 8.72 Bb and 0.21% BB, with allelic frequencies of 95.43 b and 4.57% B, adhering to Hardy-Weinberg equilibrium. These findings suggest that gene polymorphisms, particularly at the BsmIlocus, play an essential role in bone health and osteoporosis treatment. Genotype-based drug selection reduced adverse reactions from 14 to two cases. These findings improve clinical treatment efficacy and guide rational drug use for osteoporosis patients.
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| http://dx.doi.org/10.1080/17410541.2024.2366152 | DOI Listing |
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