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Objective: To examine the impact of increased body mass index (BMI) on (1) tracheotomy timing and (2) short-term surgical complications requiring a return to the operating room and 30-day mortality utilizing data from the Multi-Institutional Study on Tracheotomy (MIST).
Methods: A retrospective analysis of patients from the MIST database who underwent surgical or percutaneous tracheotomy between 2013 and 2016 at eight institutions was completed. Unadjusted and adjusted logistic regression analyses were used to assess the impact of obesity on tracheotomy timing and complications.
Results: Among the 3369 patients who underwent tracheotomy, 41.0% were obese and 21.6% were morbidly obese. BMI was associated with higher rates of prolonged intubation prior to tracheotomy accounting for comorbidities, indication for tracheotomy, institution, and type of tracheostomy (p = 0.001). Morbidly obese patients (BMI ≥35 kg/m) experienced a longer duration of intubation compared with patients with a normal BMI (median days intubated [IQR 25%-75%]: 11.0 days [7-17 days] versus 9.0 days [5-14 days]; p < 0.001) but did not have statistically higher rates of return to the operating room within 30 days (p = 0.12) or mortality (p = 0.90) on multivariable analysis. This same finding of prolonged intubation was not seen in overweight, nonobese patients when compared with normal BMI patients (median days intubated [IQR 25%-75%]: 10.0 days [6-15 days] versus 10.0 days [6-15 days]; p = 0.36).
Conclusion: BMI was associated with increased duration of intubation prior to tracheotomy. Although morbidly obese patients had a longer duration of intubation, there were no differences in return to the operating room or mortality within 30 days.
Level Of Evidence: 3 Laryngoscope, 134:4674-4681, 2024.
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http://dx.doi.org/10.1002/lary.31586 | DOI Listing |
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Information Network Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objectives: Increasing detection of low-risk papillary thyroid carcinoma (PTC) is associated with overdiagnosis and overtreatment. N6-methyladenosine (mA)-mediated microRNA (miRNA) dysregulation plays a critical role in tumor metastasis and progression. However, the functional role of mA-miRNAs in PTC remains unclear.
View Article and Find Full Text PDFCurr Hypertens Rev
September 2025
Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Introduction: Epidemiological evidence suggests that people with hemophilia (PWH) have a higher prevalence of comorbidities compared to the general population. However, the incidence and risk of comorbidities, particularly hypertension, among Mexican PWH remain underexplored.
Methods: We conducted a retrospective cross-sectional study on adult PWH at a major hemophilia treatment center in Mexico.
J Hum Nutr Diet
October 2025
School of Health, Medicine and Life Sciences, University of Hertfordshire, Hatfield, UK.
Background: Evidence suggests that women should eat a healthy diet during pre-conception and pregnancy as this benefits their own health as well as reducing the risk of non-communicable diseases in offspring (such as obesity, diabetes, hypertension, cardiovascular and mental health problems); however, previous work indicates that the recommendations are not being followed. This study aimed to understand: the facilitators and barriers to healthy food and diet practices during pre-conception and pregnancy; how these barriers could be addressed, and the changes required to facilitate good food practices.
Methods: The research used a qualitative approach; five online focus groups were undertaken with 19 women living across the UK who were trying to conceive, pregnant or had babies under 6-months old.
Obesity (Silver Spring)
September 2025
Laboratorio de Neurociencia Sensorial, Perceptual y Cognitiva, Instituto de Ciencias de la Salud, Universidad de O'Higgins, Rancagua, Chile.
In recent years, it has been suggested that the development of obesity could affect the auditory system, altering its functionality and its ability to process sound. However, little research exists on the molecular and physiological mechanisms underlying this relationship, especially in humans. This narrative review aims to highlight the research supporting the role of obesity as both an independent risk factor for hearing loss and as a condition that may exacerbate age-related hearing loss, providing an analysis of the molecular mechanisms underlying these processes.
View Article and Find Full Text PDFExpert Rev Pharmacoecon Outcomes Res
September 2025
Health Economics Unit, School of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Introduction: The global obesity epidemic is a complex issue influenced by various factors, including the food system and its environment. Increasingly, interventions targeting systemic changes in the food environment are being implemented to address obesity. Cost-benefit analysis (CBA) is gaining recognition as a valuable tool for evaluating these interventions, due to its ability to capture broader societal impacts beyond health outcomes.
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