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Wastewater surveillance (WWS) has received significant attention as a rapid, sensitive, and cost-effective tool for monitoring various pathogens in a community. WWS is employed to assess the spatial and temporal trends of diseases and identify their early appearances and reappearances, as well as to detect novel and mutated variants. However, the shedding rates of pathogens vary significantly depending on factors such as disease severity, the physiology of affected individuals, and the characteristics of pathogen. Furthermore, pathogens may exhibit differential fate and decay kinetics in the sewerage system. Variable shedding rates and decay kinetics may affect the detection of pathogens in wastewater. This may influence the interpretation of results and the conclusions of WWS studies. When selecting a pathogen for WWS, it is essential to consider it's specific characteristics. If data are not readily available, factors such as fate, decay, and shedding rates should be assessed before conducting surveillance. Alternatively, these factors can be compared to those of similar pathogens for which such data are available.
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http://dx.doi.org/10.1016/j.scitotenv.2024.173862 | DOI Listing |
BMC Public Health
September 2025
Department of Mathematics, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Gottlieb-Daimler-Str.48, Kaiserslautern, 67663, Germany.
We study the dynamics of coexisting influenza and SARS-CoV-2 by adapting a well-established age-specific COVID-19 model to a multi-pathogen framework. Sensitivity analysis and adjustment of the model to real-world data are used to investigate the influence of age-related factors on disease dynamics. Our findings underscore the critical role that transmission rates play in shaping the spread of influenza and COVID-19.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2025
Department of Planned Immunization, Chaoyang District Centre for Disease Control and Prevention, Beijing, China.
Mumps is a vaccine-preventable disease. Following Beijing's implementation of a three-dose MMR vaccination strategy, incidence rates declined significantly. However, the current 21-d quarantine period lacks evidence-based support, resulting in low compliance and conflicts between healthcare providers and patients.
View Article and Find Full Text PDFDiagn Cytopathol
September 2025
Department of General Surgery, Qianwei Hospital of Jilin Province, Changchun, China.
Colorectal cancer (CRC) is a major global health burden, ranking among the leading causes of cancer-related deaths. Despite improvements in screening and treatment, challenges such as late-stage diagnosis, high recurrence rates, and therapy resistance continue to impede optimal outcomes. Liquid biopsy, a minimally invasive technique that analyzes tumor-derived components in bodily fluids-including circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and extracellular vesicles (EVs)-is emerging as a powerful tool to transform CRC management across the disease continuum.
View Article and Find Full Text PDFWater Res
August 2025
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an, 710069, China; The Collaboration Unit for State Key Laboratory of Infectious Disease Prevention and Control, Jiangxi Provincial Health Commission Key Laborat
Human parainfluenza virus (HPIV) and human rhinovirus (HRV) significantly contribute to acute respiratory tract infections (ARIs), especially in children. Wastewater surveillance (WWS) is a valuable tool for monitoring these viruses, but limited understanding of their fecal shedding patterns restricts the broader application of WWS. This study aimed to investigate fecal shedding dynamics of HPIV and HRV for developing a mass-balance model to predict infection prevalence, and conduct wastewater sequencing to explore genetic diversity.
View Article and Find Full Text PDFJ Parasit Dis
September 2025
Department of Medical Parasitology, Faculty of Medicine, Misr University for Science and Technology, 6th October city, Giza, Egypt.
Cryptosporidiosis is an enteric infection caused by The severity of the disease depends mainly on the immune status of the host. The infection is self-limited in immunocompetent individuals but in immunocompromised patients, it can be severe and threatening. To provide new insights into a better understanding of the pathogenesis of the infection and the impact of immune modulation on the course of the disease, we used 4 groups of Swiss-Albino mice; dexamethasone (DEX) group, the diabetic group, the DEX-infected group, and the diabetic-infected group.
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