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bacteremia arises due to skin inoculation from the external environment or translocation from the gastrointestinal tract. In the event of bacteremia, it tends to colonize in anaerobic environments due to its obligatory anaerobic nature. Its inoculation in the lung, albeit rare, can occur if an anaerobic nidus is created. In the presented case, the patient developed bacteremia andempyema in the area of lung necrosis caused by acute pulmonary embolism. He did not have any history of chest trauma, and the source of bacteremia was deemed to be via gut translocation. The patient was noted to have multiple gastric ulcers on endoscopy and jejunal wall thickening, which likely led to the bacterial translocation into the bloodstream. He underwent video-assisted thoracoscopic surgery-assisted decortication and intravenous antibiotics, eventually leading to clinical improvement. To identify the source of in the absence of penetrating trauma, a thorough gastrointestinal evaluation, including a colonoscopy, is warranted to identify the pathology leading to the gastrointestinal translocation.
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http://dx.doi.org/10.7759/cureus.60082 | DOI Listing |
FEBS Open Bio
September 2025
Graduate School of Pharmaceutical Sciences, The University of Osaka, Suita, Japan.
Tight junctions (TJs) are formed where two or three cells meet and are therefore categorized, respectively, into bicellular TJs (bTJs) and tricellular TJs (tTJs). Angubindin-1 is the first tTJ modulator enhancing intestinal macromolecule permeation via binding to the key tTJ proteins, angulin-1 and angulin-3. It is a fragment (amino acids 421-664) derived from domain IV of Clostridium perfringens iota toxin.
View Article and Find Full Text PDFCureus
August 2025
General Surgery, Sree Balaji Medical College and Hospital, Chennai, IND.
Gas gangrene is a rare, life-threatening infection caused mainly by and other species, such as , , , and . Other microbial pathogens also reported to cause gas gangrene are and . It is fulminant and associated with high rates of morbidity and mortality, especially in patients with underlying comorbidities such as diabetes mellitus.
View Article and Find Full Text PDFPoult Sci
August 2025
Optima Life Sciences Private Limited, Pune Maharashtra, 411009, India.
Antibiotic growth promoters (AGPs) are increasingly subject to global regulatory restrictions and consumer pressure, driving the poultry industry toward antibiotic-free production systems. This shift has accelerated the search for effective alternatives, including innovative microbial additives, organic acids, phytogenics, and other bioactive compounds capable of supporting digestive function and enhancing immune competence in poultry. The present study reported the isolation and characterization of a novel Bacillus velezensis strain, BV-OLS1101, possessing robust probiotic attributes and a distinctive capacity to produce a serine protease subtilisin.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Heilongjiang Provincial Key Laboratory of Zoonosis, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China. Electronic address:
Subunit vaccines offer high biosafety but face limited immunogenicity. In this study, we utilized a biomimetic mineralization strategy, rhamnolipid-modified manganese-doped calcium phosphate nanoparticles (RMCP), to enhance the immunogenicity of subunit vaccines based on-bacterial-like particle (BLPs). Subcutaneous administration of the developed vaccine, which is prepared by encapsulating BLP vaccine with RMCP (named RMCP@COB17) enhanced significantly elevated serum IgG antibody levels in mice, induced a Th1/Th2-balanced immune response, and promoted the secretion of cytokines such as IFN-γ and IL-12.
View Article and Find Full Text PDFISME Commun
January 2025
Center for Applied Microbiome Science, Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, United States.
Human excrement composting (HEC) is a sustainable strategy for human excrement (HE) management that recycles nutrients and mitigates health risks while reducing reliance on freshwater, fossil fuels, and fertilizers. A mixture of HE and bulking material was collected from 15 composting toilets and composted as 15 biological replicates in modified 19-liter buckets under mesophilic conditions with weekly sampling for one year. We hypothesized that (i) the microbiome of 1 year old compost would resemble that of a soil and/or food and landscape waste compost microbiome more closely than the original HE; and (ii) the human fecal indicators, and , would be undetectable after 52 weeks using qPCR and culturing.
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