Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The use of nanomaterial-based radiosensitizers to improve the therapeutic ratio has gained attraction in radiotherapy. Increased radiotoxicity applied to the tumor region may result in adverse impact on the unexposed normal cells to the radiation, a phenomenon known as radiation-induced bystander effect (RIBE).
Objectives: This study aimed to investigate the effect of BiS@BSA nanoparticles (NPs) as radiosensitizers on the enhancement of bystander response in non-irradiated cells.
Materials And Methods: Lung carcinoma epithelial cells were exposed to 6 MV x-ray photons at different doses of 2 and 8 Gy, with and without BiS@BSA NPs. The irradiated-cell's conditioned medium (ICCM) was collected and incubated with MCR-5 human fetal lung fibroblasts.
Results: This study showed that ICCM collected from 2-Gy-irradiated A549 cells in the presence of BiS@BSA NPs reduced the cell viability of MCR-5 bystander cells more than ICCM collected from irradiated cells without NPs (<0.05), whereas such a difference was not observed after 8-Gy radiation. The mRNA expression of the BAX and XPA genes, as well as the cell death rate in MCR-5 bystander cells, revealed that the BiS@BSA NPs significantly improved bystander response at 2-Gy (<0.05), but the efficacy was not statistically significant after 8-Gy Irradiation.
Conclusion: The results indicated that the presence of NPs did not affect bystander response enhancement at higher concentrations. These findings highlighted the potential use of radiation-enhancing agents and their benefits in radiotherapy techniques with high doses per fraction.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139445 | PMC |
| http://dx.doi.org/10.30498/ijb.2024.385844.3629 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Implementation status, drivers and barriers to the sick children quality of care improving interventions in the Oromia region, Ethiopia: case study design.
BMC Health Serv Res
May 2025
Faculty of Public Health, Department of Health Policy and Management, Jimma University, Jimma, Ethiopia.
Background: Improving quality of sick child care is the primary aim of Integrated Community Case Management services and implementation fidelity is critical to translating an evidence-based intervention to practice. A community-based complex intervention was implemented at the health posts of four agrarian regions of Ethiopia from 2017 to 2018 to improve the coverage and utilization of quality child health services. This study aimed to examine the implementation status of child health care quality improvement interventions in program areas of Oromia region, Ethiopia.
View Article and Find Full Text PDFThe 'Health-2-Go' programme's impact on all-cause mortality and clinic utilisation for children 5 and under: a retrospective cohort analysis of an iCCM intervention in Ghana's Barekese Subdistrict.
BMJ Glob Health
March 2025
Department of Community Health, Ensign Global University, Kpong, Eastern Region, Ghana.
Introduction: The 'Health-2-Go' programme, which incorporates the integrated community case management strategy, aims to enhance healthcare access in rural Ghana by deploying trained and equipped community-based agents to manage the diagnosis and treatment of basic illness for children aged 5 and under. This study evaluates the intervention's impact on all-cause mortality and clinical healthcare utilisation among children 5 and under in the Barekese Subdistrict in the Atwima Nwabiagya North District of the Ashanti Region of Ghana.
Methods: A retrospective cohort study was conducted using data from 2530 children across nine communities exposed to Health-2-Go and six comparison communities with no Health-2-Go exposure.
The Probiotics , , and Enhance Spermatozoa Motility Through Mitochondrial Function-Related Factors.
Int J Mol Sci
December 2024
Department of Biomedical Science, College of Life Science, CHA University, Pocheon 11160, Gyeonggi-do, Republic of Korea.
Idiopathic male infertility is characterized by increased mortality or reduced motility and vitality of sperm. There are several reports on probiotics in the male reproductive tract, but the effects of these probiotics on sperm motility remain to be elucidated. In this study, we investigated the impact and mechanism of probiotics on the vitality and motility of mouse sperm.
View Article and Find Full Text PDFRole of damaged mitochondrial transfer in alpha-particle generator Pb radiation-induced bystander effect.
Theranostics
October 2024
Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Pb, a promising alphaparticle generator of Bi, has aroused much interest as a therapeutic radionuclide. For the development of targeted alpha therapy (TAT), it is important to determine the contribution of targeted effects in irradiated cells, and also of non-targeted effects in non-irradiated bystander cells. Currently, the critical roles of mitochondrial transfer in cellular crosstalk have garnered significant attention.
View Article and Find Full Text PDFEfficient Induction of Apoptosis in Lung Cancer Cells Using Bismuth Sulfide Nanoparticles.
Iran J Biotechnol
January 2024
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Article Synopsis
- This study examines how BiS@BSA nanoparticles function as radiosensitizers to enhance the bystander effect in non-irradiated lung cells during radiotherapy.
- Lung carcinoma cells were irradiated with x-ray photons, and their conditioned medium was tested on human lung fibroblast cells to assess the impact of these nanoparticles.
- Results showed that at a lower radiation dose (2 Gy), the nanoparticles significantly increased cell death in bystander cells, but this effect diminished at higher doses (8 Gy), suggesting limitations in their use at elevated radiation levels.