Green synthesis and toxicological evaluation of zinc oxide nanoparticles utilizing Punica granatum fruit Peel extract: an eco-friendly approach.

The green synthesis approach for nanoparticle production offers several advantages over traditional physical and chemical methods. Notably, it avoids the use of hazardous chemicals and acts as a cost-effective and eco-friendly process. This study focuses on the green synthesis of zinc oxide nanoparticles (ZnO- NPs) using the Punica granatum fruit peel extract.

Computational modeling and experimental synthesis of BSA-coated bimetallic theranostic MnO₂-Au@curcumin nanoplatform for synergistic radiochemotherapy of breast cancer.

This study details the design, synthesis, and validation of the novel MnO₂-Au-BSA@CUR construct, utilizing a tightly integrated computational (Docking, DFT, MD) and experimental approach to understand its structure and function, and demonstrating significant in vitro synergistic radiosensitization as a key outcome for potential breast cancer therapy. The nanoparticles, comprising manganese dioxide (MnO) for oxygen generation, gold (Au) for radiosensitization, bovine serum albumin (BSA) for biocompatibility, and curcumin (CUR) for dual chemotherapeutic and radioprotective effects, were synthesized and characterized using techniques such as UV-Vis spectroscopy, XRD, FTIR, and TEM, confirming their uniform morphology and successful conjugation. As shown in the TEM image, the average size of MnO-Au-BSA@CUR nanoparticles is about 39.

Preparation and characterization of niosomes containing silver nanoparticles as a radiosensitizer for enhancing radiotherapy of the lung cancer.

Lung cancer was associated with a high mortality rate. However, the critical challenges in radiotherapy are enhancing tumor damage and minimize the side effects to the healthy tissues. A strategic approach to overcome this challenge includes using different radiosensitizer to increase the efficiency of radiotherapy while reducing side effects on normal tissues.

Green synthesis of silver sulfide quantum dots using tarragon and evaluation of cytotoxic effect on HFF2 cells.

Due to their special features, quantum dots have recently attracted the attention of researchers in the fields of imaging, drug delivery, and cancer treatment. In this study, we prepared AgS quantum dots (QDs) intending to control the nucleus growth and reduce toxicity in Artemisia dracunculus (tarragon) extract substrate using the green synthesis method. Synthesized nanoparticles were analyzed using different characterization techniques.

A comprehensive study on methylene blue removal via polymer and protein nanoparticle adsorbents.

Water pollution, particularly from industrial contaminants such as dyes, is a significant global concern. Various technologies, including nanoscale materials, are employed for water and wastewater treatment. Among these, adsorption process as an effective method due to its simplicity, cost-effectiveness, and reliability.

Removal of the nalidixic acid antibiotic from aqueous solutions using bovine serum albumin nanoparticles.

The presence of antibiotic pollutants in water and wastewater can cause significant risks to the environment in different aspects. Therefore, antibiotics need to be removed from water. This study investigates the adsorption of nalidixic acid (NA), a common antibiotic, using bovine serum albumin nanoparticles (BSA NPs).

Investigating the Size Effect of Metal-Organic Frameworks in Drug Delivery and Anticancer Properties.

Here, we show particle size-dependent therapeutic efficacy with a Zn-based metal-organic framework (MOF). The size of MOFs was tuned in specific ranges (∼100, 200, and 300 nm) built upon the manipulation of synthetic conditions. X-ray photoelectron spectroscopy, infrared, PXRD, and dynamic light scattering and scanning electron microscopy analyses were used to identify the synthesized structures.

Photothermal and radiotherapy with alginate-coated gold nanoparticles for breast cancer treatment.

Radiation therapy and phototherapy are commonly used cancer treatments that offer advantages such as a low risk of adverse effects and the ability to target cancer cells while sparing healthy tissue. A promising strategy for cancer treatment involves using nanoparticles (NPs) in combination with radiation and photothermal therapy to target cancer cells and improve treatment efficacy. The synthesis of gold NPs (AuNPs) for use in biomedical applications has traditionally involved toxic reducing agents.

Multi-wall carbon Nanotube surface-based functional nanoparticles for stimuli-responsive dual pharmaceutical compound delivery.

Carbon nanotubes (CNTs) have the potential to serve as delivery systems for medicinal substances and gene treatments, particularly in cancer treatment. Co-delivery of curcumin (CUR) and Methotrexate (MTX) has shown promise in cancer treatment, as it uses fewer drugs and has fewer side effects. This study used MTX-conjugated albumin (BSA)-based nanoparticles (BSA-MTX) to enhance and assess the efficiency of CUR.

Cationic micelle delivery of a multi-epitope vaccine candidate derived from tumor-associated antigens, causing regression in established CT26 colorectal tumors in mice.

Among all the cancers, colorectal cancer (CRC) has the third mortality rank in both genders. Cancer vaccines have shown promising results in boosting patients' immune systems to fight cancer. Using the IEDB database, we predicted mouse MHC-I (H2-Ld) binding epitopes from four tumor-associated antigens (APC, KRAS, TP53, and PIK3CA) and designed a multi-epitope vaccine.

Magnetic ferrite nanoparticles coated with bovine serum albumin and glycine polymers for controlled release of curcumin as a model.

To conquer the low water solubility and bioavailability of curcumin (CUR), to corroborate its functional qualities and to broaden its applicability in the pharmaceutical sector, numerous nanoscale methods have been widely exploited for its administration. Because of its polycystic, biodegradable, biocompatibility, non-toxicity, and non-allergenic properties, bovine serum albumin (BSA) and glycine (Gly) have been actively investigated as natural biopolymers for decades. Various BSA and Gly-based nanocarriers with unique features for CUR delivery, such as magnetic ferrite nanoparticles, are being developed (MNPs).

Facile preparation of silver based radiosensitizers via biomineralization method for enhanced in vivo breast cancer radiotherapy.

To solve the traditional radiotherapy obstacles, and also to enhance the radiation therapy efficacy various radiosensitizers have been developed. Radiosensitizers are promising agents that under X-ray irradiation enhance injury to tumor tissue by accelerating DNA damage. In this report, silver-silver sulfide nanoparticles (Ag-AgS NPs) were synthesized via a facile, one-pot and environmentally friendly biomineralization method.

Characterization of Polyethyleneimine-Oleic Acid Cationic Micelle as a Novel Protein Carrier.

Background: Nanotechnology has introduced valuable carriers for vaccine delivery. The success of vaccination depends on many factors, such as the intact and safe presentation of vaccine candidates to immune cells. We have conjugated branched PEI-2k and oleic acid (OL) as the building block of the cationic micelle.

Synthesis of single-walled carbon nanotubes functionalized with platinum nanoparticles to sense breast cancer cells in 4T1 model to X-ray radiation.

In recent years, various types of radiosensitizers have been developed to address the challenges of cancer radiotherapy. Here, platinum-functionalized oxygenated single-walled carbon nanotubes (O-SWCNTs-Pt) coated with folic acid (FA) and bovine serum albumin (BSA) (O-SWCNTs-Pt-BSA-FA) were synthesized, characterized, and used as radiosensitizers to improve the therapeutic efficacy of X-rays in a mouse model of breast cancer (4T1) in vitro. The nanosensitizer was characterized by different techniques, such as transmission electron microscopy (TEM), selected area electron diffraction (SAED), dynamic light scattering (DLS), zeta potential, X-ray diffraction (XRD), ultraviolet-visible (UV-visible), and Fourier transform infrared (FTIR) spectrometry.

Synthesis of FeO-Gold hybrid nanoparticles coated by bovine serum albumin as a contrast agent in MR imaging.

Despite the over spatial separation and the ability to determine soft tissues, insufficient contrast is the shortcoming of magnetic resonance imaging (MRI) that could be circumvented by the use of contrast agents. The use of MRI contrast agents are widely applied to enhance the vision of internal body structures. Nano-sized contrast materials have unique application advantages compared to other contrast agents due to their size and shape.

Targeted co-delivery of methotrexate and chloroquine via a pH/enzyme-responsive biocompatible polymeric nanohydrogel for colorectal cancer treatment.

Application of conventional chemotherapy regardless of its unique effectiveness have been gradually being edged aside due to limited targeting capability, lack of selectivity and chemotherapy-associated side effects. To this end, colon-targeted nanoparticles combination therapy have shown great therapeutic potential against cancer. Herein, pH/enzyme-responsive biocompatible polymeric nanohydrogels based on poly(methacrylic acid) (PMAA) containing methotrexate (MTX) and chloroquine (CQ) were fabricated.

Enhancing the Neuroprotection Potential of Edaravone in Transient Global Ischemia Treatment with Glutathione- (GSH-) Conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery.

Ischemic stroke is the most common among various stroke types and the second leading cause of death, worldwide. Edaravone (EDV) is one of the cardinal antioxidants that is capable of scavenging reactive oxygen species, especially hydroxyl molecules, and has been already used for ischemic stroke treatment. However, poor water solubility, low stability, and bioavailability in aqueous media are major EDV drawbacks.

Bovine serum albumin-mediated synthesis and quorum sensing inhibitory properties of Ag-AgS nanoparticles.

Quorum sensing (QS) is a density-dependent chemical process of cell-to-cell communication in which certain signals are activated, leading to the coordination of pathogenic behaviors and the regulation of virulence in bacteria. Inhibition of QS can prevent biofilm formation and reduce virulence behaviors of bacteria. Herein, bovine serum albumin (BSA)-coated silver nanoparticles (NPs) (Ag-AgS@BSA NPs) were synthesized and studied as an anti-QS agent.

Synthesis and characterization of bovine serum albumin-coated copper sulfide nanoparticles as curcumin nanocarriers.

Cancer is among the most common causes of death in the world that affects a large number of people every year. Curcumin is one of the natural anticancer therapeutics with little or no negative effects. However, due to its hydrophobic nature, poor bioavailability, limited gastrointestinal uptake, and fast metabolism, its therapeutic applications are constrained.

Silver sulfide coated alginate radioenhancer for enhanced X-ray radiation therapy of breast cancer.

A wide range of high-Z nanomaterials are fabricated to decrease radiation dose by sensitizing cells to irradiation through various mechanisms such as ROS generation enhancement. Alginate-coated silver sulfide nanoparticles (AgS@Alg) were synthesized and characterized by SEM, TEM, DLS, XRD, EPS, FT-IR, and UV-vis analysis techniques. Cytotoxicity of nanoparticles was tested against HFF-2, MCF-7, and 4 T1 cell lines for biocompatibility and radio enhancement ability evaluation, respectively.

Targeted CuFeO hybrid nanoradiosensitizers for synchronous chemoradiotherapy.

Multifunctional nanoplatforms based on novel bimetallic nanoparticles have emerged as effective radiosensitizers owing to their potential capability in cancer cells radiosensitization. Implementation of chemotherapy along with radiotherapy, known as synchronous chemoradiotherapy, can augment the treatment efficacy. Herein, a tumor targeted nanoradiosensitizer with synchronous chemoradiotion properties, termed as CuFeO@BSA-FA-CUR, loaded with curcumin (CUR) and modified by bovine serum albumin (BSA) and folic acid (FA) was developed to enhance tumor accumulation and promote the anti-cancer activity while attenuating adverse effects.

Evaluation of PLGA nanoparticles containing outer membrane proteins of bacterium in stimulating the immune system in mice.

Background And Purpose: is known as a pathogen with antibiotic resistance, causing respiratory infections. PLGA has been approved for use in vaccines as well as drug delivery. This study was performed to evaluate PLGA nanoparticles containing the outer membrane proteins (OMPs) of in stimulating the mice's immune system and improving pneumonia.