Green synthesis and toxicological evaluation of zinc oxide nanoparticles utilizing Punica granatum fruit Peel extract: an eco-friendly approach.

The green synthesis approach for nanoparticle production offers several advantages over traditional physical and chemical methods. Notably, it avoids the use of hazardous chemicals and acts as a cost-effective and eco-friendly process. This study focuses on the green synthesis of zinc oxide nanoparticles (ZnO- NPs) using the Punica granatum fruit peel extract.

Preparation and characterization of niosomes containing silver nanoparticles as a radiosensitizer for enhancing radiotherapy of the lung cancer.

Lung cancer was associated with a high mortality rate. However, the critical challenges in radiotherapy are enhancing tumor damage and minimize the side effects to the healthy tissues. A strategic approach to overcome this challenge includes using different radiosensitizer to increase the efficiency of radiotherapy while reducing side effects on normal tissues.

Computer-aided diagnosis of Haematologic disorders detection based on spatial feature learning networks using blood cell images.

Analyzing biomedical images is vital in permitting the highest-performing imaging and numerous medical applications. Determining the analysis of the disease is an essential stage in handling the patients. Similarly, the statistical value of blood tests, the personal data of patients, and an expert estimation are necessary to diagnose a disease.

Green synthesis of silver sulfide quantum dots using tarragon and evaluation of cytotoxic effect on HFF2 cells.

Due to their special features, quantum dots have recently attracted the attention of researchers in the fields of imaging, drug delivery, and cancer treatment. In this study, we prepared AgS quantum dots (QDs) intending to control the nucleus growth and reduce toxicity in Artemisia dracunculus (tarragon) extract substrate using the green synthesis method. Synthesized nanoparticles were analyzed using different characterization techniques.

An intelligent ransomware based cyberthreat detection model using multi head attention-based recurrent neural networks with optimization algorithm in IoT environment.

The rapid growth of the Internet of Things (IoT) and its extensive use in many regions, such as smart homes, healthcare, and vehicles, have made IoT security increasingly critical. Ransomware is an advanced and adjustable threat influencing users globally, limiting admittance to their data or systems over models like file encryption or screen locking. Traditional ransomware detection methods frequently drop, deprived of the ability to combat these threats successfully.

A multi-model feature fusion based transfer learning with heuristic search for copy-move video forgery detection.

Protecting data from management is a significant task at present. Digital images are the most general data representation. Images might be employed in many areas like social media, the military, evidence in courts, intelligence fields, security purposes, and newspapers.

Privacy-preserving approach for IoT networks using statistical learning with optimization algorithm on high-dimensional big data environment.

In the present digital scenario, the explosion of Internet of Things (IoT) devices makes massive volumes of high-dimensional data, presenting significant data and privacy security challenges. As IoT networks enlarge, certifying sensitive data privacy while still employing data analytics authority is vital. In the period of big data, statistical learning has seen fast progressions in methodological practical and innovation applications.

Anomaly Detection in Embryo Development and Morphology Using Medical Computer Vision-Aided Swin Transformer with Boosted Dipper-Throated Optimization Algorithm.

Infertility affects a significant number of humans. A supported reproduction technology was verified to ease infertility problems. In vitro fertilization (IVF) is one of the best choices, and its success relies on the preference for a higher-quality embryo for transmission.

Niosomes loaded with gold nanoparticles for enhanced radiation therapy in lung cancer.

The present investigation aimed to develop niosomes containing gold nanoparticles (Nio-AuNPs) and to evaluate the combinational effect of Nio-AuNPs and x-ray radiation therapy (XRT) on growth inhibition potential and induction of apoptosis in the A549 cell line. Gold nanoparticles (AuNPs) were synthesized, and niosomes were prepared using the thin-film hydration method. Various techniques were employed to determine their physiochemical characteristics.

Suppress the cell growth of cancer stem-like cells (NTERA-2) using Sox2-Oct4 decoy oligodeoxynucleotide-encapsulated niosomes-zinc hybrid nanocarriers under X-irradiation.

Sox2 and Oct4 dysregulations could significantly increase in the cancer stem cell (CSC) population in some cancer cells and resistance to common treatments. In this study, the synergistic effects of Sox2-Oct4 decoy oligodeoxynucleotides-encapsulated Niosomes-zinc hybrid nanocarriers along with X-irradiation conditions as a combinational therapy tool were investigated in the treatment of cancer-like stem cells (NTERA-2). The NTERA-2 cell line known as a cancer-like stem cell line was used in this investigation.

Photothermal and radiotherapy with alginate-coated gold nanoparticles for breast cancer treatment.

Radiation therapy and phototherapy are commonly used cancer treatments that offer advantages such as a low risk of adverse effects and the ability to target cancer cells while sparing healthy tissue. A promising strategy for cancer treatment involves using nanoparticles (NPs) in combination with radiation and photothermal therapy to target cancer cells and improve treatment efficacy. The synthesis of gold NPs (AuNPs) for use in biomedical applications has traditionally involved toxic reducing agents.

The role of gender differences in the outcome of juvenile social isolation: Emphasis on changes in behavioral, biochemical and expression of nitric oxide synthase genes alteration.

Social isolation can cause serious problem in performance of individuals in community. As gender differences may cause variation results in the severity of depressive behavior and response of patients to therapy, the impact of gender and the interaction of the level of endocrine secretion in depression were investigated in this study. Wistar rats of both sexes were subjected to post-weaning social isolation (PWSI) conditions and, together with the control group, experienced several behavioral tests including open-field Test (OFT), elevated plus maze (EPM), force swimming test (FST), splash test and novel object recognition test (NOR).

Separation of crude methanol extract of root: identification of phytochemicals and assessment of biological activities.

root extracts were used for analysis by Gas Chromatography-Mass Spectrometry (GC-MS). The anticancer and antibacterial functions of extracts were also investigated. The dichloromethane extract of had the highest inhibitory effect against (18.

Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells.

In the present study, we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer cells. Myc decoy ODNs were designed based on the promoter of gene and analyzed by molecular docking and molecular dynamics assays. ODNs were loaded on the synthesized Se@BSA@Chi-MTX nanostructure.

Combinational therapy with Myc decoy oligodeoxynucleotides encapsulated in nanocarrier and X-irradiation on breast cancer cells.

The Myc gene is the essential oncogene in triple-negative breast cancer (TNBC). This study investigates the synergistic effects of combining Myc decoy oligodeoxynucleotides-encapsulated niosomes-selenium hybrid nanocarriers with X-irradiation exposure on the MDA-MB-468 cell line. Decoy and scramble ODNs for Myc transcription factor were designed and synthesized based on promoter sequences of the gene.

Edaravone Improved Behavioral Abnormalities, Alleviated Oxidative Stress Inflammation, and Metabolic Homeostasis Pathways in Depression.

Depression is one of the main factors affecting our daily performance. Among many putative compounds with effect on behavioral and pathophysiological alterations in depression, edaravone (EDV) demonstrates antioxidant and free radical scavenging properties. To investigate possible antidepressive and anxiolytic-like effects of EDV, Wistar rats were randomly divided into six groups: (1) control; (2) EDV (6 mg/kg); (3) post weaning social isolation (PWSI); (4) PWSI+EDV (1.

Antiproliferative assay of suma or Brazilian ginseng () methanolic extract on HCT116 and 4T1 cancer cell lines, toxicity on larvae, and antibacterial activity.

is a medicinal plant used in folk medicine and a subject of commercial interest. The cytotoxicity effects from root extracts on cancerous and normal cells were assessed by the MTT method, and toxicity was evaluated on . The inhibition of the proliferation of bacteria and MIC values were examined by the disc diffusion and the broth microdilution method, respectively.

Synthesis of Pt nanoparticles with gelatin-assisted green route to improve sensitization of cancer cells to X-Ray irradiation.

This study aimed to develop a novel radiosensitizer consisting of platinum nanoparticles (Pt NPs) as a high-atomic-number element in order to maximize the generation of ROS under ionizing radiation at the tumor site. Pt NPs were produced via a green and facile method in the presence of gelatin (Gel) as both reducing and stabilizing agent. After determining the physical structure and chemical composition of Pt@Gel NPs by STEM, FeSEM, EDS, DLS, XRD and FTIR, in vitro cytotoxicity on human umbilical vein endothelial cells (HUVEC) and breast cancer cell line (4T1) was evaluated by MTT assay.

Bovine serum albumin-mediated synthesis and quorum sensing inhibitory properties of Ag-AgS nanoparticles.

Quorum sensing (QS) is a density-dependent chemical process of cell-to-cell communication in which certain signals are activated, leading to the coordination of pathogenic behaviors and the regulation of virulence in bacteria. Inhibition of QS can prevent biofilm formation and reduce virulence behaviors of bacteria. Herein, bovine serum albumin (BSA)-coated silver nanoparticles (NPs) (Ag-AgS@BSA NPs) were synthesized and studied as an anti-QS agent.

High-frequency adventitious shoot organogenesis from stem explants of Grossh.

The present study introduced an shoot organogenesis protocol for the medicinal plant (Lamiaceae). Stem, leaf, and petiole explants were cultured in half-strength Murashige and Skoog (MS) medium containing different concentrations of 6-benzylaminopurine (BAP) alone or in combination with thidiazuron (TDZ), indole-3-butyric acid (IBA), or α-naphthalene acetic acid. Callus formation occurred from stem and petiole explants in most cultures; however, in leaf explants, it was observed only in cultures containing 0.

Correlation between coenzyme Q content and the nutrient sensors in AKI induced by envenomation.

Acute kidney injury (AKI) may have a negative effect on mitochondrial hemostasis and bioenergetics as well as coenzyme Q (CoQ) content. PGC-1α, AMPK, sirtuin 1 (Sirt1), and Sirt3, as the key metabolic regulators under nutritional stress, stimulate energy production mitochondrial biogenesis during AKI. However, no report is available on the relationship between CoQ level and nutrient sensors in the pathophysiology of AKI caused by scorpion envenomation.

The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression.

The comorbidity of depression and high risk of cardiovascular diseases (CVD) have been reported as major health problems. Our previous study confirmed that fluoxetine (FLX) therapy had a significant influence on brain function but not on the heart in depression. In the present study, suberoyanilide hydroxamic acid (SAHA) was proposed as another therapeutic candidate for treatment of depression comorbid CVD in maternal separation model, following behavioral analyses and gene expression level in the heart.

Biogenic and facile synthesis of selenium nanoparticles using Vaccinium arctostaphylos L. fruit extract and anticancer activity against in vitro model of breast cancer.

Biogenic synthesis of selenium nanoparticles (SeNPs) using plant extracts has emerged as a promising alternative approach to traditional chemical synthesis. The current study aims to introduce a safe, low-cost, and green synthesis of SeNPs using fresh fruit extract of Vaccinium arctostaphylos L. The biogenic synthesis of SeNPs was confirmed by different analyses including ultraviolet-visible spectrophotometry, Fourier transform infrared, and energy-dispersive X-ray.

Clavulanic Acid: A Novel Potential Agent in Prevention and Treatment of Scopolamine-Induced Alzheimer's Disease.

: Alzheimer's disease (AD) is the most common form of dementia in the elderly. It is characterized as a multifaced disorder with a greater genetic contribution. The contribution of many genes such as , , and has been reported in the pathogenesis of AD.

elicitation and detection of apigenin, catalpol and gallic acid in hairy root culture of L. and assessment of cytotoxicity and anti-bacterial activity of its methanolic extract.

The aim of this study was to establish the hairy root (HR) culture of to evaluate the accumulation of apigenin, catalpol and gallic acid after elicitation and investigate the biological activity of its methanolic extraction. The highest transformation frequency was obtained by strain A4, 0.5 mg/L 6-Benzylaminopurine in pre-cultivation medium, 150 µM acetosyringone in co-cultivation medium (1/2 MS), and immersion method for inoculation of leaf explants.