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Objective: To investigate the clinical manifestations, imaging and pathological features, treatment methods and prognosis of primary leiomyosarcoma of kidney, and the choice of treatment with tumor thrombus.
Methods: The clinical data of a patient with primary renal leiomyosarcoma complicated with inferior vena cava and right atrial tumor thrombus were retrospectively analyzed. Radical resection of right kidney without cardiopulmonary bypass and removal of inferior vena cava and right atrial tumor thrombus were performed. Adjuvant intravenous chemotherapy was given according to the results, and follow-up observation was made.
Results: Postoperative pathological findings were: leiomyosarcoma (right renal tumor), the size of the mass was about 12.1 cm, and no cancer was found at the incision end of the right ureter.
Conclusion: Primary leiomyosarcoma of kidney is rare in clinical practice, and complication of right atrial tumor embolus is even rarer. The disease has high malignant degree and poor prognosis. The clinical manifestations and imaging examinations were non-specific, and pathological diagnosis was the gold standard. Radical surgical resection is the main treatment method at present, and it provides experience for the treatment of grade IV tumor thrombus without cardiopulmonary bypass.
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http://dx.doi.org/10.3389/fonc.2024.1385073 | DOI Listing |
Aim Search for subclinical manifestations of cardiotoxicity in cancer patients at high and very high risk of cardiotoxicity and evaluation of the effectiveness of drug primary prevention during the antitumor treatment. Material and methods The study included 150 cancer patients with a high and very high Mayo Clinic (USA) Cardiotoxicity Risk Score. The main group consisted of 84 patients at high and very high risk of cardiotoxicity who were prescribed cardioprotective therapy, including a fixed combination of the angiotensin-converting enzyme inhibitor (ACEI) perindopril and the beta-blocker bisoprolol with trimetazidine.
View Article and Find Full Text PDFJACC Case Rep
September 2025
Department of Cardiac Surgery, Prince Sultan Cardiac Center, Al-Hassa, Saudi Arabia. Electronic address:
Background: Cardiac tumors are rare, with most being benign. Vascular cardiac tumors, such as hemangiomas, account for 1% to 2% of all cardiac tumors.
Case Summary: We present a case of a 53-year-old woman who presented with palpitations and shortness of breath.
Eur Heart J
September 2025
Institute of Pharmacology and Toxicology, University Medical Centre Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany.
Background And Aims: Atrial fibrillation (AF) is a prevalent complication after cardiac surgery, worsening patient outcomes. Considering the established role of Ca2+-handling abnormalities in AF pathogenesis, this study aimed to evaluate if integrating cytosolic Ca2+-handling measurements with clinical risk factors enhances the risk prediction of post-operative AF.
Methods: Clinical data from 558 patients undergoing cardiac surgery without pre-existing AF from two centres were analysed.
JACC Case Rep
September 2025
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address:
Background: Masses in the right ventricle are uncommon, but if present, they are most often attributed to either primary cardiac tumors or metastatic disease.
Case Summary: A 50-year-old woman presented with progressive lower extremity edema and was diagnosed with a right ventricular mass causing severe tricuspid insufficiency and near-total obstruction of the pulmonary artery. She had a history of hysterectomy for uterine leiomyomatosis.
JACC Case Rep
September 2025
Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China. Electronic address:
Background: Intra-atrial cysts are rare and often mistaken for neoplastic lesions. Vascular-origin cysts are even more uncommon. Limited genetic data hamper understanding of their pathogenesis and management.
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