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http://dx.doi.org/10.1038/s41433-024-03143-9 | DOI Listing |
Innov Aging
August 2025
Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, China.
Background And Objectives: This study aimed to investigate the relationship between mental work, work intensity, and accelerated biological aging, focusing on the mediating role of the Visceral Adiposity Index (VAI).
Research Design And Methods: In this cross-sectional study, data were collected from the Kailuan physical activity cohorts in the Asia-Pacific region. Biological aging was assessed using PhenoAge and Klemera-Doubal method age (KDMAge) acceleration.
Front Aging Neurosci
August 2025
Department of Prosthodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, China.
Introduction: Alzheimer's Disease (AD) is a common neurodegenerative disease among the elderly population. It has been posited that the onset and progression of AD are influenced by a combination of various factors. Occlusal support loss due to tooth loss has been reported to be a risk factor triggering cognitive dysfunction.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
August 2025
Division of Biochemistry and Molecular Biology, Siberian State Medical University, Ministry of Health of the Russian Federation, 634050 Tomsk, Russia.
Background: Sarcopenia is a complex, multifactorial condition characterized by progressive loss of muscle mass, strength, and function. Despite growing awareness, the early diagnosis and pathophysiological characterization of this condition remain challenging due to the lack of integrative biomarkers.
Objective: This study aimed to conduct a comprehensive multilevel profiling of clinical parameters, immune cell phenotypes, extracellular vesicle (EV) signatures, and biochemical markers to elucidate biological gradients associated with different stages of sarcopenia.
Int J Biol Macromol
September 2025
Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. Electronic address:
Skin aging serves as a critical indicator of systemic health decline. Despite Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) being a key therapeutic target, mechanistic understanding remains incomplete and potent, safe activators are lacking, hindering clinical progress. This study proposes the "Barrier-Skin-Systemic Aging Axis," demonstrating that epidermal barrier disruption accelerates aging via PPARγ suppression.
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