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Article Abstract
(Bagnall), the main pest on legume vegetables, is controlled by pyrethroids in the field. Field strains of resistant to pyrethroids were collected from three areas in Hainan Province (Haikou, Ledong, and Sanya City), and two mutations, T929I and K1774N, were detected in the voltage-gated sodium channel. In this study, the sodium channel in was first subcloned and successfully expressed in oocytes. The single mutation (T929I or K1774N) and double mutation (T929I/K1774N) shifted the voltage dependence of activation in the hyperpolarization direction. The three mutants all reduced the amplitude of tail currents induced by type I (permethrin and bifenthrin) and type II (deltamethrin and λ-cyhalothrin) pyrethroids. Homology modeling analysis of these two mutations shows that they may change the local hydrophobicity and positive charge of the sodium channel. Our data can be used to reveal the causes of the resistance of to pyrethroids and provide guidance for the comprehensive control of in the future.
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| http://dx.doi.org/10.1021/acs.jafc.4c00355 | DOI Listing |
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