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Access to contraceptive services during the COVID-19 pandemic: clients' perspective at primary health care level from India, Nigeria and Tanzania.
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Department of Sexual and Reproductive Health including UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, World Health Organization, Avenue Appia 20, 1211, Geneva, Switzerland.
Background: The COVID-19 pandemic disrupted the provision of sexual and reproductive health services, including contraceptive and family planning (FP) services. The World Health Organization conducted a multi-country study in India, Nigeria and Tanzania to assess the impact of the pandemic on the health system's capacity to provide contraceptive and FP services. In this paper, we share the results of a qualitative study aimed at understanding clients' perspectives at the primary healthcare level on accessing contraceptive services in COVID-19-affected areas in the three aforementioned countries.
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Radioresistance poses a significant obstacle in the management of Non-Small Cell Lung Cancer (NSCLC), often diminishing the effectiveness of radiotherapy and leading to treatment failures and adverse clinical outcomes. This study develops radioresistant NSCLC models, revealing that Secreted Protein Acidic and Rich in Cysteine (SPARC) as a crucial modulator of this resistance, through the inhibition of ferroptosis. To address this radioresistance, we propose a novel ferroptosis-oriented radiosensitization strategy specifically designed to enhance radiotherapy effectiveness in radioresistant NSCLC.
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