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http://dx.doi.org/10.1007/s12011-024-04195-4 | DOI Listing |
Antioxidants (Basel)
August 2025
Diabetes Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha P.O. Box 34110, Qatar.
A dietary supplement, -resveratrol and hesperetin (tRES+HESP)-also known as GlucoRegulate-induces increased expression of glyoxalase 1 (Glo1) by activation of transcription factor Nrf2, countering accumulation of the reactive dicarbonyl glycating agent, methylglyoxal. tRES+HESP corrected insulin resistance and decreased fasting and postprandial plasma glucose and low-grade inflammation in overweight and obese subjects in a clinical trial. The aim of this study was to explore, for the first time, health-beneficial gene expression other than Glo1 induced by tRES+HESP in human endothelial cells and fibroblasts in primary culture and HepG2 hepatoma cell line and activity of -resveratrol (cRES) as a Glo1 inducer.
View Article and Find Full Text PDFOdontology
August 2025
Department of Basic Medical Sciences, Faculty of Dentistry, Near East University, Nicosia, Cyprus.
Eur J Pharmacol
August 2025
Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address:
Sirtuin 1 (SIRT1) has emerged as a promising therapeutic target for many diseases such as neurodegenerative disorders. Resveratrol, a plant polyphenol, is known to induce SIRT1 expression and activity. To excavate active compounds that can increase SIRT1 transcription from FDA-approved drugs, a cell-based SIRT1 up-regulator screening assay was developed.
View Article and Find Full Text PDFJ Chromatogr A
September 2025
Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, PR China. Electronic address:
The quantification of stilbenes in pigeonpea (Cajanus cajan (L.) Millsp.) is critical for its development as a medicinal resource.
View Article and Find Full Text PDFCells
July 2025
Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale "A. Avogadro", Via Solaroli 17, 28100 Novara, Italy.
In the original publication [...
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