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It is important for surgeons performing sarcoma surgery to know that bone resection and tumor prosthesis applications in soft tissue sarcomas (STS) have unique features in terms of indication, surgical approach and follow-up, in terms of the management of these cases. Some STS are associated with bone and major neurovascular structures. Bone-associated STS are generally relatively large and relatively deep-seated. Additionally, the tendency for metastasis is high. In some cases, the decision about which structures to resect is difficult. These cases are often accompanied by poor oncological and surgical outcomes. Management of cases should be done by a multidisciplinary team in advanced centers specialized in this field. The surgical team must have sufficient knowledge and experience in the field of limb-sparing surgery. Preoperative evaluation and especially good planning of bone and soft tissue reconstruction are vital.
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http://dx.doi.org/10.12998/wjcc.v12.i12.2004 | DOI Listing |
Mater Horiz
September 2025
MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, PR China.
Globular proteins, traditionally regarded as non-structural biomolecules due to the limited load-bearing capacity in their monomeric states, are increasingly recognized as valuable building blocks for functional-mechanical materials. Their inherent bioactivity, chemical versatility, and structural tunability enable the design of materials that combine biological functionality with tailored mechanical performance. This review highlights recent advances in engineering globular proteins-spanning natural systems (serum albumins, enzymes, milk globulins, silk sericin, and soy protein isolates) to recombinant architectures including tandem-repeat proteins-into functional-mechanical platforms.
View Article and Find Full Text PDFChemSusChem
September 2025
Stokes Laboratories, School of Engineering, Bernal Institute, University of Limerick, Limerick, V94 T9PX, Ireland.
The development of mechanically robust, biocompatible, and biodegradable hydrogels remains a significant challenge for biomedical applications involving load-bearing soft tissues. Herein, a tubular lignin-derived hydrogel is engineered to assess its physicochemical, mechanical, and biological properties. Kraft and organosolv lignin are systematically compared at varying crosslinker concentrations to determine their effect on pore morphology, swelling behavior, and mechanical performance.
View Article and Find Full Text PDFAnn Surg Oncol
September 2025
Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Soft tissue sarcomas (STS) are a heterogeneous group of rare malignant tumors arising from mesenchymal tissues, with extremity and superficial trunk STS (eSTS) comprising the majority of cases. The management of localized eSTS requires a multidisciplinary approach to optimize oncologic and functional outcomes. This review outlines the natural history, diagnostic workup, and treatment principles for localized eSTS, emphasizing the role of histology-specific considerations in guiding management strategies.
View Article and Find Full Text PDFEmerg Med J
September 2025
Department of Emergency Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
Background: Civilians in South Africa experience a high incidence of crush injury, or traumatic rhabdomyolysis. Community assault (CA) is a common mechanism of crush injury in South Africa, where victims are assaulted by multiple persons using a variety of objects. A crush injury places patients at risk of renal dysfunction.
View Article and Find Full Text PDFJ Prosthet Dent
September 2025
Associate Professor, Department of Dental Surgery, Faculty of Dental Surgery, University of Malta, Malta. Electronic address:
A digital workflow merging root submergence, immediate dental implant and definitive intermediate abutment placements, and custom healing abutment fabrication to enhance esthetic and biological outcomes in immediate implant procedures is described. The procedure involves a prosthetically driven plan on intraoral and cone beam computed tomography (CBCT) scans, digital planning using a specialized software program, the creation of a surgical guide, and the digital design of custom components. A 3-dimensionally (3D) printed healing abutment was produced by following specific protocols.
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