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Article Abstract
Two new sesterterpenoids, atractylodes japonica terpenoid acid I (1) and atractylodes japonica terpenoid aldehyde I (2), were isolated from the rhizomes of Atractylodes japonica Koidz. ex Kitam together with ten known compounds (3-12). Their structures were elucidated on the basis of comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS and IR). In addition, all of these isolated compounds were evaluated for their cytotoxic activities against human gastric cancer cell MGC-803 and human hepatocellular cancer cell HepG-2. Most of them exhibited moderate to weak inhibitory effects with IC values in the range of 25.15-88.85 μM except for 9-12.
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Article Synopsis
- * Their chemical structures were determined using advanced techniques like spectroscopy and mass spectrometry, with absolute configurations confirmed through electronic circular dichroism calculations.
- * The new compounds were tested for their ability to kill cancer cells, showing that one compound was effective against three types of cancer cells (HT-29, A-549, and MCF-7), while the other was effective against only two (HT-29 and MCF-7).