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http://dx.doi.org/10.1186/s12894-024-01477-w | DOI Listing |
J Biopharm Stat
September 2025
Biostatistics and Research Decision Sciences, Merck & Co. Inc., North Wales, Pennsylvania, USA.
A randomized clinical trial with multiple experimental groups and one common control group is often used to speed up development to select the best experimental regimen or to increase the chance of success of clinical trials. Most of the time, multiple dose levels of an experimental drug or multiple combinations of one experimental drug with other drugs comprise multiple experimental groups. Because the experimental drug appears in multiple comparisons with a shared control group, multiple testing adjustments to control the family-wise type I error rate are needed.
View Article and Find Full Text PDFActa Ophthalmol
September 2025
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Purpose: To evaluate visual, anatomical and safety outcomes of aflibercept 8 mg in previously treated patients with neovascular age-related macular degeneration (nAMD).
Methods: This retrospective study included nAMD patients switched to aflibercept 8 mg from prior anti-VEGF therapies at Sahlgrenska University Hospital between February 2024 and February 2025. Data on best-corrected visual acuity (BCVA), central retinal thickness (CRT), pigment epithelial detachment (PED) height, fluid status, treatment intervals, time to fluid recurrence and adverse events were collected.
PLoS Comput Biol
September 2025
Mathematical and Statistical Methods (Biometris), Wageningen University, Wageningen, The Netherlands.
Many plant cell functions, including cell morphogenesis and anisotropic growth, rely on the self-organisation of cortical microtubules into aligned arrays with the correct orientation. An important ongoing debate is how cell geometry, wall mechanical stresses, and other internal and external cues are integrated to determine the orientation of the cortical array. Here, we demonstrate that microtubule-based nucleation can markedly shift the balance between these often competing directional cues.
View Article and Find Full Text PDFVestn Oftalmol
September 2025
Krasnov Research Institute of Eye Disease, Moscow, Russia.
Phacoemulsification with intraocular lens (IOL) implantation has become the standard method for cataract extraction regardless of its etiology. In modern phaco surgery, implantation of multifocal IOLs is considered the most advanced method for correcting aphakia following lens extraction. The wide range of available multifocal IOLs is promoting the ongoing discussion regarding the advantages of each type, as well as potential strategies for optimizing surgical outcomes.
View Article and Find Full Text PDFJ Med Imaging (Bellingham)
September 2025
Vanderbilt University, Data Science Institute, Nashville, Tennessee, United States.
Purpose: Recent developments in computational pathology have been driven by advances in vision foundation models (VFMs), particularly the Segment Anything Model (SAM). This model facilitates nuclei segmentation through two primary methods: prompt-based zero-shot segmentation and the use of cell-specific SAM models for direct segmentation. These approaches enable effective segmentation across a range of nuclei and cells.
View Article and Find Full Text PDF