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The synthesis and characterization of porphyrin center regulated three-dimensional covalent organic frameworks (COFs) with 2-fold interpenetrated scu or sqc topology have been investigated. These COFs exhibit unique structural features and properties, making them promising candidates for photocatalytic applications in CO reduction and artemisinin synthesis. The porphyrin center serves as an anchor for metal ions, allowing precise control over structures and functions of the frameworks. Furthermore, the metal coordination within the framework imparts desirable catalytic properties, enabling their potential use in photocatalytic reactions. Overall, these porphyrin center regulated metal-controlled COFs offer exciting opportunities for the development of advanced materials with tailored functionalities.
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http://dx.doi.org/10.1002/anie.202404156 | DOI Listing |
Nat Commun
September 2025
Center for Advancing Electronics Dresden & Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, Dresden, Germany.
The synthesis of thin crystalline two-dimensional polymers (2DPs) typically relies on reversible dynamic covalent reactions. While substantial progress has been made in solution-based and interfacial syntheses, achieving 2DPs through irreversible carbon-carbon coupling reactions remains a formidable challenge. Herein, we present an on-liquid surface (a mixture of N,N-dimethylacetamide and water, DMAc-HO) synthesis method for constructing diyne-linked 2DP (DY2DP) crystals via Glaser coupling, assisted by a perfluoro-surfactant (PFS) monolayer.
View Article and Find Full Text PDFInt J Nanomedicine
September 2025
School of Pharmaceutical Sciences, Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, People's Republic of China.
Purpose: This study aimed to develop a composite nanozyme system (Au/PB-Ce6-HA) based on gold nanoparticles (AuNPs) and Prussian blue nanoparticles (PBNPs) to combat tumor hypoxia and insufficient endogenous hydrogen peroxide (HO) deficiency, thus enhancing the efficacy of sonodynamic therapy (SDT) and starvation therapy for liver cancer.
Methods: The Au/PB-Ce6-HA system was constructed by in situ embedding AuNPs on PBNPs, loading the sonosensitizer Chlorin e6 (Ce6), and surface-coating with thiolated hyaluronic acid (HA-SH). The system was evaluated both in vitro and in vivo to assess its ability to catalyze glucose to generate HO, decompose HO to produce oxygen, and generate highly toxic reactive oxygen species (ROS) under ultrasound irradiation.
Acta Crystallogr E Crystallogr Commun
September 2025
College of Materials Science and Opto-electronic Technology University of Chinese Academy of Sciences, Huairou Beijing 101408 People's Republic of China.
The title complex, [Fe(CHN)(CHN)]·3CH, possesses inversion symmetry with the iron(II) atom located on a center of symmetry. The metal atom is coordinated in a symmetric octa-hedral geometry by four pyrrole N atoms of the porphyrin ligand in the equatorial plane and two N atoms of 1-methyl-imidazole ligands in the axial sites; the complex crystallizes with three toluene solvent mol-ecules. The average Fe-N (N is a porphyrin N atom) bond length is 1.
View Article and Find Full Text PDFDalton Trans
September 2025
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India.
The spontaneous formation of an ordered array of twisted cobalt(II) porphyrins yields a 2D self-assembled structure that is then wrapped around multiwalled carbon nanotubes (MWCNTs) and characterized using different techniques. The structure of β-tetracyano--tetraphenylporphyrinatocobalt(II) (2-Co) shows axial ligation of the metal center with cyano groups when it is adsorbed on the nanotube sidewalls, and the nanotube acts as a template for the formation of the framework layer. The electrocatalytic applications of the formed conjugate are explored in terms of the activity and the selectivity in the oxygen reduction reaction (ORR) in basic media.
View Article and Find Full Text PDFOxid Med Cell Longev
September 2025
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke Cancer Institute, Duke University School of Medicine, Durham 27710, North Carolina, USA.
Numerous cellular and animal studies demonstrated the ability of redox-active Mn(III) -alkyl- and -alkoxyalkylpyridyporphyrins (MnPs) to protect normal tissue while suppressing tumor growth. The mechanism primarily involves the modulation of NF-кB and Nrf2 signaling pathways via catalysis of MnP/HO-driven protein thiol oxidation. Such differential protection/suppression effects have paved the way of Mn porphyrins (commonly known as mimics of superoxide dismutase) into clinical trials, therefore introducing new line of therapeutics that are affecting cellular redox status/oxidative stress, rather than specific proteins.
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