Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Aberrant cognitive network activity and cognitive deficits are established features of chronic pain. However, the nature of cognitive network alterations associated with chronic pain and their underlying mechanisms require elucidation. Here, we report that the claustrum, a subcortical nucleus implicated in cognitive network modulation, is activated by acute painful stimulation and pain-predictive cues in healthy participants. Moreover, we discover pathological activity of the claustrum and a region near the posterior inferior frontal sulcus of the right dorsolateral prefrontal cortex (piDLPFC) in migraine patients during acute pain and cognitive task performance. Dynamic causal modeling suggests a directional influence of the claustrum on activity in this piDLPFC region, and diffusion weighted imaging verifies their structural connectivity. These findings advance understanding of claustrum function during acute pain and provide evidence of a possible circuit mechanism driving cognitive impairments in chronic pain.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cub.2024.03.021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Digital health and Buddhist network philosophy.
BJPsych Bull
September 2025
Department of Psychiatry, Kyoto University, Kyoto, Japan.
Heated online communication reveals global challenges in the digital age, often fuelled by collective outrage. This article investigates how Buddhist network perspectives, paralleling digital reality, can inform mental health. Avatamsaka philosophy provides practical ways to navigate web complexities, suggesting that individual actions ripple across society.
View Article and Find Full Text PDFCognitive Compensation Depends on Frontoparietal Network Structure-Function Coupling in Patients With White Matter Hyperintensity.
Brain Behav
September 2025
Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Background And Purpose: White matter hyperintensity (WMH) impairs cognitive function but is not evident in the early stage, raising the need to explore the underlying mechanism. We aimed to investigate the potential role of network structure-function coupling (SC-FC coupling) in cognitive performance of WMH patients.
Methods: A total of 617 participants with WMH (mean age = 61 [SD = 8]; 287 females [46.
Prefrontal Network Mechanisms of Psychiatric Deep Brain Stimulation.
J Neurosci
September 2025
Psychiatry, University of Minnesota, Minneapolis, Minnesota 55455
Deep brain stimulation (DBS) is an emerging treatment for otherwise treatment-refractory psychiatric disorders. It can produce remarkable clinical results in expert hands, but has not fared as well in controlled, multisite trials. That difficulty with scaling up arises in part because DBS' mechanisms are poorly understood, meaning that it is difficult to objectively identify patients likely to respond and/or to customize stimulation to match individual patients' needs.
View Article and Find Full Text PDFKetamine and Esketamine for Late-Life Depression: A Systematic Review of Efficacy, Safety, and Tolerability.
Am J Geriatr Psychiatry
August 2025
Mood Disorder and Psychopharmacology Unit (RS, JKT, CED, RSM), University Health Network, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronnto, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, ON, Canada. Electronic address: roger.mcintyre@
Ketamine has emerged as a promising treatment for major depression, though its efficacy and safety remain incompletely characterized in older adults. This systematic review synthesizes current evidence for ketamine in geriatric depression. A search of PubMed, EMBASE, and PsycINFO was conducted.
View Article and Find Full Text PDFPrenatal alcohol exposure perturbs the development of radial glial cells in the fetal olfactory bulb.
Alcohol Clin Exp Res (Hoboken)
September 2025
Department of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Background: Prenatal alcohol exposure (PAE) causes fetal alcohol spectrum disorder (FASD) and is associated with various cognitive and sensory impairments, including olfactory dysfunction. While both genetic and environmental factors contribute to olfactory dysfunction, PAE is considered a significant factor affecting brain development, including the olfactory system. In this study, we investigated the impact of PAE on the developing olfactory bulb (OB), specifically focusing on OB RGCs-radial glial cells that give rise to OB projection neurons.
View Article and Find Full Text PDF