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The cochlear tonotopic map determines where along the basilar membrane traveling waves of different frequencies peak. Endolymphatic hydrops has been hypothesized to shift the tonotopic map by altering the stiffness of the cochlear partition, especially in the apex. In this exploratory study performed in a handful of normal and hydropic ears, we report preliminary measurements of interaural differences assayed using behavioral pitch-matching supplemented by measurements of reflection otoacoustic-emission phase-gradient delays.
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http://dx.doi.org/10.1063/5.0189381 | DOI Listing |
Neurotoxicology
September 2025
Department of Otolaryngology Head and Neck Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China. Electronic address:
Gadolinium-based contrast agents (GBCAs) are widely used in systemic magnetic resonance imaging (MRI) and can be employed in otology to evaluate endolymphatic hydrops in patients with Ménière's disease. Given the heavy metal properties of gadolinium and its tendency to deposit in tissues, it is essential to assess its ototoxic risk. We evaluated the ototoxicity of gadodiamide using in vitro and in vivo models.
View Article and Find Full Text PDFJ Neuroimmunol
September 2025
Department of Otorhinolaryngology Head and Neck Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Department of Vertigo Diagnosis and Treatment Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address:
Background: Ménière's disease (MD) remains a heterogeneous disorder with unclear pathogenesis. While immune dysregulation has been implicated, the specific role of CD4+ T cell subsets and their clinical correlations in MD are poorly understood.
Methods: We performed comprehensive immune profiling of 30 MD patients and 27 healthy controls using flow cytometry to analyze six CD4+ T cell subsets (Th1, Th2, Th17, Treg, TGF-β+, TNF-α+) and multiplex cytokine analysis of 16 inflammatory mediators plus IgE.
Eur J Radiol
August 2025
Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China. Electronic address:
Objective: To establish objective criteria for grading vestibular endolymphatic hydrops (EH) in Meniere's disease (MD) using 3D-real IR MRI, and investigate its clinical correlations.
Methods: Retrospective analysis of 155 MD patients (189 ears) included clinical data, audiovestibular assessments, and gadolinium-enhanced MRI. Vestibule volume (VV) and the volume of vestibular endolymph (EndV) were outlined on 3D-real IR sequence images, and the volume of vestibular endolymph was calculated by the vestibular endolymphatic ratio (ELR) to evaluate the degree of EH, analyze the correlation between the degree of EH and specific clinical features, hearing and vestibular function, and determine the optimal ELR value to differentiate each degree of effusion by using receiver operating characteristic (ROC) curve analysis.
Eur Arch Otorhinolaryngol
September 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University College of Medicine, Dankook University Hospital, Cheonan-si, Republic of Korea.
Background: Acute low-tone sensorineural hearing loss (ALHL) is frequently associated with endolymphatic hydrops. Cervical vestibular-evoked myogenic potentials (cVEMP) have been used to detect saccular hydrops, especially in Meniere's disease, but their role in ALHL is unclear.
Objective: To preliminarily investigate whether cVEMP tuning frequency shifts are associated with hearing outcomes in patients with ALHL.
Comput Biol Med
September 2025
Division of Computer Science and Artificial Intelligence, Jeonbuk National University, Jeonju, Republic of Korea; Center for Advanced Image and Information Technology (CAIIT), Jeonbuk National University, Jeonju, Republic of Korea. Electronic address:
The identification of endolymphatic hydrops (EH) using magnetic resonance imaging (MRI) is crucial for understanding inner ear disorders such as Meniere's disease and sudden low-frequency hearing loss. The EH ratio is calculated as the ratio of the endolymphatic fluid space to the perilymphatic fluid space. We propose a novel cross-channel feature transfer (CCFT) 3D U-Net for fully automated segmentation of the perilymphatic and endolymphatic fluid spaces in hydrops MRI.
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