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http://dx.doi.org/10.1038/s41392-024-01786-4 | DOI Listing |
Medicine (Baltimore)
September 2025
Department of Orthopedics, Lhasa People's Hospital, Lhasa, China.
Rheumatoid arthritis (RA) is an autoimmune condition characterized by widespread and persistent inflammation. In this study, we sought to investigate the association between the systemic inflammation response index (SIRI) and the likelihood of RA occurrence among individuals in the United States. This study conducted a retrospective analysis using data collected from the National Health and Nutrition Examination Survey from 1999 to 2020.
View Article and Find Full Text PDFPLoS One
September 2025
Laboratory of Molecular and Cellular Immunology, Institute of Molecular Biology, National Academy of Sciences, Yerevan, Armenia.
The short lifespan of polymorphonuclear neutrophils (PMNs) in vitro poses challenges, as their limited viability restricts functional assays and experimental manipulations. The HL-60 cell line serves as a valuable model for neutrophil-like differentiation, yet the functional relevance of ATRA- and DMSO-induced differentiation remains incompletely understood. In the present study, we aimed to characterize the differentiation potential of all-trans retinoic acid (ATRA) and dimethyl sulfoxide (DMSO) on HL-60 cells and compare their functionality with primary PMNs.
View Article and Find Full Text PDFMol Nutr Food Res
September 2025
Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao, China.
The relationship between dietary biotin intake and cognitive function remains unclear. This study explores the association between biotin and dementia, and the mediating role of inflammation indicators. Dietary biotin intake was assessed via the 24-h recall questionnaire.
View Article and Find Full Text PDFLow Urin Tract Symptoms
September 2025
Department of Urology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Objectives: This study aims to examine the association of systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) with the prevalence of overactive bladder (OAB).
Methods: This cross-sectional study analyzed data from 22,343 participants (≥ 20 years) in the National Health and Nutrition Examination Survey (2005-2018). We applied weighted multivariate logistic regression, restricted cubic spline (RCS) regression, subgroup, and sensitivity analyses to assess the associations between SII, NLR, and OAB.
Front Neurol
August 2025
Department of Neurology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.
Background: Systemic inflammation and immune responses are key contributors to the onset and progression of ischemic stroke, influencing both tissue damage and repair. This study investigates the association between the pan-immune inflammatory value (PIV)-a composite biomarker derived from routine blood tests-and all-cause mortality (ACM) in critically ill ischemic stroke patients.
Methods: We extracted data from the MIMIC-IV (v3.