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http://dx.doi.org/10.1007/s13193-023-01806-9 | DOI Listing |
Oncoscience
September 2025
Department of Surgical Oncology, Consultant Surgical Oncologist, Alluri Sitaramaraju Academy of Medical Sciences, Eluru, Andhra Pradesh 534005, India.
Adult fibrosarcoma is a rare and aggressive soft tissue malignancy originating from spindle-shaped fibroblasts, primarily affecting deep soft tissues in the extremities, trunk, head, and neck. Surgical resection with R0 margins remains the gold standard, with adjuvant radiation therapy recommended for large or high-grade tumors to reduce recurrence risk. Chemotherapy and immunotherapy play complementary roles in disease management, with emerging strategies targeting matrix metalloproteinases and tumor microenvironment interactions to enhance chemosensitivity and overcome drug resistance.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Liangzhou Hospital, Wuwei, China.
Rationale: High-grade myofibroblastic sarcoma (HGMS) is a rare mesenchymal tumor with a high recurrence and metastatic rate. Few cases of high-grade myofibroblastic sarcomas have been reported. Herein, we report the first case of HGMS originating from the thyroid.
View Article and Find Full Text PDFGenes Chromosomes Cancer
July 2025
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Recurrent KMT2A and YAP1 related fusions have recently been reported in various mesenchymal neoplasms of different histogenesis. First, YAP1::KMT2A fusions have been described in a subset of MUC4-negative sclerosing epithelioid fibrosarcomas (SEF), while VIM::KMT2A fusions in a handful of cases associated with an undifferentiated spindle cell phenotype lacking stromal hyalinization. On the other hand, YAP1 gene rearrangements have been reported in a wide spectrum of sarcomas, including vascular neoplasms such as epithelioid hemangioendothelioma (EHE).
View Article and Find Full Text PDFCase Rep Endocrinol
August 2025
Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Thyroid gland fibrosarcomas are very rare tumors, with only very few cases have been reported in the literature. Their similarity to anaplastic thyroid cancer poses a diagnostic challenge, often leading to misdiagnosis. We report the case of an 87-year-old female with a history of left thyroid nodule who underwent a left lobectomy and subsequently, received levothyroxine therapy.
View Article and Find Full Text PDFCureus
July 2025
Department of Periodontics, Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre, Hyderabad, IND.
Ameloblastic fibroma (AF) is a rare non-cancerous growth in the jaw that involves abnormal development of the epithelial and connective tissue parts of a tooth. A 33-year-old female presented with bleeding gums, mobile anterior mandibular teeth, and persistent halitosis. Initial oral examination and orthopantomogram revealed a unilocular radiolucent lesion with partially sclerotic borders, associated with an unerupted supernumerary tooth in the mandibular ramus.
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