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Hypertension remains the leading modifiable risk factor for cardiovascular disease worldwide. Over the past 30 years, the prevalence of hypertension has been increasing in East and Southeast Asia to a greater extent as compared with other Western countries. Asians with hypertension have unique characteristics. This can be attributed to increased impact of obesity on Asians with hypertension, excessive salt intake and increased salt sensitivity, loss of diurnal rhythm in blood pressure and primary aldosteronism. The impact of hypertension on cardiovascular (particularly strokes) and chronic kidney disease is greater in Asians. These unique characteristics underpinned by the diverse socioeconomic backgrounds pose its own challenges in the diagnosis and management of hypertension in Asia.
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http://dx.doi.org/10.1097/HJH.0000000000003706 | DOI Listing |
Inorg Chem
September 2025
The Key Laboratory of the Materials for Energy Conversion and Storage of Shanxi Province, Institute of Molecular Science, Shanxi University, 92 Wucheng Road, Taiyuan, Shanxi 030006, People's Republic of China.
For over half a century, clusters exhibiting unconventional bonding have captivated researchers due to their unique electronic characteristics. While most elements in the periodic table demonstrate this remarkable structural feature, sulfur has been notably absent from known global minima with a planar pentacoordinate center. Herein, we report the first binary dianion cluster, SMg, featuring a planar pentacoordinate sulfur (ppS) atom.
View Article and Find Full Text PDFJ Chem Phys
September 2025
Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, India.
We introduce a novel method using a kilohertz (kHz) amplified 800 nm laser for the first experimental confinement of microparticles within a single beam. This study demonstrates that high-energy kHz pulses can confine 1-μm-radius polystyrene beads in water within ∼26 μm. This approach utilizes the unique properties of high-energy pulsed lasers, distinct from continuous-wave and megahertz pulsed lasers traditionally used in optical trapping.
View Article and Find Full Text PDFJ Chem Phys
September 2025
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang Province 310027, China.
Sum-frequency generation vibrational spectroscopy (SFG-VS) has been well-established as a unique spectroscopic probe to interrogate the structure, interaction, and dynamics of molecular interfaces, with sub-monolayer sensitivity and broad applications. Sub-1 cm-1 High-Resolution Broadband SFG-VS (HR-BB-SFG-VS) has shown advantages with high spectral resolution and accurate spectral line shape. However, due to the lower peak intensity for the long picosecond pulse used in achieving sub-wavenumber resolution in the HR-BB-SFG-VS measurement, only molecular interfaces with relatively strong signal have been studied.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
Faculty of Engineering, University of Technology Sydney, P.O. Box 123, Broadway, Sydney, NSW, 2007, Australia.
Microalgae-bacteria symbiosis system is significant for sustainable and low-carbon wastewater treatment, with self-aggregation being key to its stable operation and effective pollutant removal. Cellular motility is the main driving force behind self-aggregation, crucial for symbiosis stability, but the characteristics and patterns involved still remain largely unexplored. Here, cellular movement dynamics into the microalgae-activated sludge model (ASM3) is incorporated, enabling synchronized simulation of metabolic activities and movement behaviors through physical and biochemical interactions in bioreactor systems.
View Article and Find Full Text PDFJ Pharm Anal
August 2025
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
P-glycoprotein (P-gp) is a transmembrane protein widely involved in the absorption, distribution, metabolism, excretion, and toxicity (ADMET) of drugs within the human body. Accurate prediction of P-gp inhibitors and substrates is crucial for drug discovery and toxicological assessment. However, existing models rely on limited molecular information, leading to suboptimal model performance for predicting P-gp inhibitors and substrates.
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