98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948429 | PMC |
http://dx.doi.org/10.3389/fspor.2024.1389519 | DOI Listing |
Neuropsychopharmacology
September 2025
Center for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
This report sought to employ multi-modal integration of pre-treatment brain (electroencephalogram, resting-state functional magnetic resonance imaging) and blood (immune and metabolic) biomarkers to facilitate causal inference-based treatment selection by virtue of establishing predictability of remission to multi-stage antidepressant treatment. Data from two stages of pharmacotherapy in the 'Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care for Depression' (EMBARC) study from participants with both brain and blood biomarkers were included (N = 197). Participants were initially randomized to sertraline or placebo (Stage 1), and depending on clinical response at week-8, their therapy in Stage 2 was either maintained or switched (to sertraline, if a non-responder to placebo, or to bupropion, if a non-responder to sertraline).
View Article and Find Full Text PDFPLoS Biol
August 2025
Institute for the Interdisciplinary Study of Language Evolution, University of Zurich, Zurich, Switzerland.
Face-to-face communication in humans typically consists of a combination of vocal utterances and body language. Similarly, our closest living relatives, chimpanzees, produce multiple vocal signals alongside a wide array of manual gestures, body postures and facial expressions. In humans, the ontogenetic development of communicative behavior is known to be heavily influenced by the child's primary caretakers.
View Article and Find Full Text PDFFront Immunol
July 2025
Virginia Tech Carilion School of Medicine, Department of Health Systems and Implementation Science, Roanoke, VA, United States.
Primary immune deficiencies (PI) are rare diseases associated with frequent, severe infections, inflammatory and autoimmune diseases and/or cancer. Because of the variability in presentation, undiagnosed PI patients can be encountered by many different medical specialists. A lack of awareness of and the rarity of PI can lead to delayed diagnosis particularly among primary care physicians and non-immunology specialists.
View Article and Find Full Text PDFWorld J Gastrointest Oncol
July 2025
Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Hepatocellular carcinoma (HCC) is a prevalent and aggressive liver cancer that poses significant challenges in diagnosis and prognosis. Recent advancements in radiomics and machine learning (ML) offer promising solutions to enhance the accuracy of HCC diagnosis, treatment response prediction, and survival prognosis. Radiomics, which extracts quantitative features from medical images, captures the complex tumor heterogeneity that is often undetectable with traditional imaging methods.
View Article and Find Full Text PDFNat Commun
July 2025
National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Queen's Medical Centre, Nottingham, United Kingdom.
The impact of SARS-CoV-2 and the COVID-19 pandemic on brain health is recognised, yet specific effects remain understudied. We investigate the pandemic's impact on brain ageing using longitudinal neuroimaging data from the UK Biobank. Brain age prediction models are trained from hundreds of multi-modal imaging features using a cohort of 15,334 healthy participants.
View Article and Find Full Text PDF