LRP2 Expression in Melanoma Is Associated With a Transitory Cell State, Increased T Cell Infiltration, and Is Upregulated by IFNy Signaling.

Low density lipoprotein receptor-related protein 2 (LRP2) is a 600 kilodalton multi-ligand endocytic membrane receptor expressed in several cell types during fetal development, including neuroepithelial cells, and in select absorptive epithelial cells in the adult. In epithelial cancers, LRP2 expression is associated with a differentiated tumor cell state and better prognosis. In previous work, we found that while LRP2 is not expressed in benign naevi, it is frequently acquired in melanoma.

Evaluation of a 'Research Methods' Training Course for Novice Lived Experience Researchers.

Background: The training of lived experience researchers (LERs) for involvement in research design and conduct is a key principle to its success. However, little is known about what research methods training is acceptable and beneficial to novice LERs.

Methods: A training evaluation using a slightly modified version of the Training Acceptability Rating Scale (TARS), and a concluding stakeholder engagement workshop.

Outcomes of liver transplants utilizing donors from outside the contiguous United States.

Purpose: Expanding the liver donor pool includes reconsidering geographic characteristics. We evaluated demographics, trends, and outcomes of transplants from donors outside the contiguous US.

Methods: Adult liver-only transplants from 2010 to 2022 were categorized by donor location (mainland US vs.

Intratumoral delivery of 4-1BBL boosts IL-12-triggered anti-glioma immunity.

The standard of care in high-grade gliomas has remained unchanged in the past 20 years. Efforts to replicate effective immunotherapies in non-cranial tumors have led to only modest therapeutical improvements for patients with glioma. Here, we demonstrate that intratumoral (i.