Characterizing imaging radiation risk in a population of 8918 patients with recurrent imaging for a better effective dose.

Sci Rep

Center for Virtual Imaging Trials, Carl E. Ravin Advanced Imaging Labs, Clinical Imaging Physics Group, Medical Physics Graduate Program, Departments of Radiology, Physics, Biomedical Engineering, and Electrical and Computer Engineering, Duke University, 2424 Erwin Road, Suite 302, Durham, NC, 27710

Published: March 2024


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

An updated extension of effective dose was recently introduced, namely relative effective dose ( ), incorporating age and sex factors. In this study we extended application to a population of about 9000 patients who underwent multiple CT imaging exams, and we compared it with other commonly used radiation protection metrics in terms of their correlation with radiation risk. Using Monte Carlo methods, , dose-length-product based effective dose ( ), organ-dose based effective dose ( ), and organ-dose based risk index ( ) were calculated for each patient. Each metric's dependency to was assessed in terms of its sensitivity and specificity. showed the best sensitivity, specificity, and agreement with (R = 0.97); while yielded the lowest specificity and, along with , the lowest sensitivity. Compared to other metrics, provided a closer representation of patient and group risk also incorporating age and sex factors within the established framework of effective dose.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10940310PMC
http://dx.doi.org/10.1038/s41598-024-56516-1DOI Listing

Publication Analysis

Top Keywords

effective dose
24
radiation risk
8
incorporating age
8
age sex
8
sex factors
8
based effective
8
dose organ-dose
8
organ-dose based
8
sensitivity specificity
8
effective
6

Similar Publications

Dietary inflammatory index and the risk of colorectal adenomas and cancer: a systematic review and dose-response meta-analysis.

Nutr J

September 2025

Department of Gastroenterology and Hepatology, Hangzhou Red Cross Hospital, 208 Huancheng Dong Road, Hangzhou, 310003, Zhejiang Province, China.

Background: The potential association between dietary inflammatory index (DII) and colorectal cancer (CRC) risk, as well as colorectal adenomas (CRA) risk, has been extensively studied, but the findings remain inconclusive. We conducted this systematic review and dose-response meta-analysis to investigate the relationship between the DII and CRC and CRA.

Methods: We comprehensively searched the PubMed, Embase, Cochrane Library, and Web of Science databases for cohort and case-control studies reporting the relationship between DII and CRA, or between DII and CRC, as of 15 July 2025.

View Article and Find Full Text PDF

Purpose: The development of on-board cone-beam computed tomography (CBCT) has led to improved target localization and evaluation of patient anatomical change throughout the course of radiation therapy. HyperSight, a newly developed on-board CBCT platform by Varian, has been shown to improve image quality and HU fidelity relative to conventional CBCT. The purpose of this study is to benchmark the dose calculation accuracy of Varian's HyperSight cone-beam computed tomography (CBCT) on the Halcyon platform relative to fan-beam CT-based dose calculations and to perform end-to-end testing of HyperSight CBCT-only based treatment planning.

View Article and Find Full Text PDF

Background: Avenanthramides (AVAs) and Avenacosides (AVEs) are unique to oats (Avena Sativa) and may serve as biomarkers of oat intake. However, information regarding their validity as food intake biomarkers is missing. We aimed to investigate critical validation parameters such as half-lives, dose-response, matrix effects, relative bioavailability under single dose, and in relation to the abundance of Feacalibacterium prausnitzii, and under repeated dosing, to understand the potential applications of AVAs and AVEs as biomarkers of oat intake.

View Article and Find Full Text PDF

Background: Red blood cell (RBC) transfusion is a common intervention for anemia in preterm infants; however, its association with bronchopulmonary dysplasia (BPD) remains debated. While biological mechanisms suggest potential harm, the clinical impact of transfusion frequency on BPD incidence and severity remains unclear.

Objective: To investigate whether RBC transfusion frequency is independently associated with the risk and severity of BPD in preterm infants born before 32 weeks of gestation.

View Article and Find Full Text PDF

Radon (Rn) is a naturally occurring radioactive gas produced by the decay of uranium-bearing minerals in rocks and soils. Long-term exposure to elevated radon levels in drinking water is associated with an increased risk of stomach and lung cancers. This study aims to assess the concentration of radon in groundwater and evaluate its potential health risks in six cancer-affected districts, i.

View Article and Find Full Text PDF