Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540378 | PMC |
| http://dx.doi.org/10.3350/cmh.2024.0144 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomechanic regulation of neutrophil extracellular traps in the cardiovascular system.
Trends Immunol
September 2025
Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia; Department of Cardiometabolic Health, The University of Melbourne, Melbourne, Victoria 3010, Australia. Electronic address:
Neutrophil extracellular trap (NET) formation, or NETosis, is a key innate immune response that contributes to cardiovascular diseases, including vascular inflammation, atherosclerosis, and thrombosis. In the cardiovascular system, neutrophils encounter mechanical cues such as shear stress, matrix stiffness, and cyclic stretch that influence their activation and NET release. This review examines emerging evidence linking altered mechanotransduction to dysregulated NETosis in vascular aging and cardiovascular pathology.
View Article and Find Full Text PDFEfficacy of Step-down Infusion Method of a Novel Barbiturate Therapy for Severe Subarachnoid Hemorrhage with Intracerebral Hematoma.
Neurol Med Chir (Tokyo)
September 2025
Department of Neurosurgery, Kurume University School of Medicine.
Currently, there is no effective treatment for elevated intracranial pressure in the acute phase of subarachnoid hemorrhage. Recently, we developed "step-down infusion of barbiturate," a therapeutic strategy for severe traumatic brain injury, which decreased intracranial pressure and significantly reduced mortality without serious side effects. This study aimed to examine the efficacy of step-down infusion of barbiturate in patients with severe subarachnoid hemorrhage.
View Article and Find Full Text PDFResearch progress of DNA barcoding in precision medicine and molecular diagnosis- A review.
Anal Chim Acta
November 2025
Department of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, PR China.
Background: A DNA barcode is a short DNA fragment used to classify and identify specific organisms, taking advantage of the specificity and diversity inherent in biological molecules. Since Herbert introduced the concept in 2003, DNA barcoding has been increasingly used in precision medicine and related fields, including species identification and environmental monitoring, over the past few decades. Although numerous molecular diagnostic techniques have emerged, many face notable obstacles such as sensitivity to handling conditions, high expenses, and limitations in accuracy.
View Article and Find Full Text PDFCancer vaccines in hematologic malignancy: A systematic review of the rational and evidence for clinical use.
Best Pract Res Clin Haematol
September 2025
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA; Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, USA.
Immunotherapy, including immune checkpoint blockade, CART cells and bispecific antibodies have resulted in dramatic improvements in outcomes for patients with hematological malignancies, demonstrating the unique potency of the immune system in targeting malignant cells. The development of cancer vaccines aims to evoke an activated effector cell population and a memory response to provide long term immune surveillance to protect from relapse. Developing a potent cancer vaccine relies on identifying appropriate antigen targets, enhancing antigen presentation, and overcoming the immune suppressive milieu of the micro-environment.
View Article and Find Full Text PDFComparing Round Window Membrane Permeability Enhancers: An Animal Study.
Eur J Pharm Sci
September 2025
Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:
Intratympanic (IT) delivery of dexamethasone (DEX) is widely used for treating inner ear disorders; however, its therapeutic efficacy is limited by poor permeability of the round window membrane (RWM). This study aimed to evaluate and compare the efficacy and safety of three pharmacological agents-histamine (HIS), 3% hypertonic saline (3% HS), and sodium caprate (SC)-as adjuvants for enhancing RWM permeability and improving IT-DEX delivery in a murine model. Following IT administration of each permeability enhancer followed by DEX injection, perilymph DEX concentrations were measured using ultra-high-performance liquid chromatography, and DEX receptor expression in the organ of Corti was assessed by immunofluorescence.
View Article and Find Full Text PDF