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http://dx.doi.org/10.1136/bmjmed-2024-000855 | DOI Listing |
Ther Adv Respir Dis
September 2025
Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Background: Hermansky-Pudlak syndrome (HPS) is a rare disease characterized by excessive bleeding, oculocutaneous albinism, and pulmonary fibrosis (PF). However, few studies have systematically summarized the clinical characteristics of HPS.
Objectives: To summarize the clinical characteristics, risk factors of PF, radiological and pathological presentations, and prognostic factors in patients with HPS.
Clin Pract
July 2025
Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.
Polypharmacy, or the concurrent intake of five or more medications, is a significant issue in clinical practice, particularly in multimorbid elderly individuals. Despite its importance for patient safety, medical education often lacks systematic training in recognising and managing polypharmacy within the framework of patient-centred care. We investigated the impact of a structured learning intervention introducing polypharmacy as a chronic condition, assessing whether it enhances medical students' diagnostic competence, confidence, and interprofessional collaboration.
View Article and Find Full Text PDFEur J Epidemiol
August 2025
Health Management Center, General Practice Medical Center, Innovation Institute for Integration of Medicine and Engineering, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
The West-China Hospital Alliance Longitudinal Epidemiology Wellness (WHALE) Study establishes a robust, multidimensional database to provide comprehensive insights into health-to-disease transitions, advancing proactive healthcare and enhancing understanding of the interplay among genetic, behavioral, and environmental factors in disease. The WHALE Study includes a database and a cohort. The WHALE Database, established in 2010, integrates health check-up data from 11 hospitals, covering sociodemographic, lifestyle, medical history, and clinical data.
View Article and Find Full Text PDFJ Multimorb Comorb
August 2025
Department of Community Health Sciences, King Saud University, Riyadh, Saudi Arabia.
Background: Multimorbidity, defined as the coexistence of two or more chronic diseases in a single individual, is a growing public health challenge globally and particularly in Saudi Arabia.
Aims: This narrative review aims to synthesize existing literature on multimorbidity in Saudi Arabia by examining its prevalence, identifying gender-based differences, and highlighting the most commonly associated chronic diseases.
Methods: A structured search was conducted using PubMed, Google Scholar, and institutional databases, including Scopus and Web of Science, for English-language studies on multimorbidity in Saudi Arabia published between 2015 and 2025.
Psychogeriatrics
September 2025
National Institute of Epidemiology, Chennai, India.
Aim: Multiple comorbidities are common amongst the elderly due to shared underlying factors. We used latent class analysis (LCA) to explore the of multimorbidities amongst the elderly and their association with self-rating of health, life satisfaction, limitations in daily activities and depressive symptoms.
Methods: We utilised a subset of nationally representative survey data from the Longitudinal Aging Survey of India 2017-2018 covering elderly >= 60 years of age.