Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The peak power performance of ultrafast fiber lasers scales with fiber mode area, but large fibers host multiple modes that are difficult to control. We demonstrate a technique for single-mode operation of highly multimode fiber based on regenerative amplification. This results in a short-pulse fiber source with, to our knowledge, an unprecedented combination of features: high gain (>55 dB) with negligible amplified spontaneous emission, high pulse energy (>50 μJ), good beam quality ( ≤ 1.3), and transform-limited (300 fs) pulses from a single amplification stage. We discuss peak intensity scaling to much higher levels and other opportunities for short-pulse generation in regenerative fiber amplifiers.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10906912 | PMC |
| http://dx.doi.org/10.1364/optica.501955 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhance therapeutic efficacy of BiTE (HER2/CD3) for HER2- positive tumors through expression.
Int J Pharm X
December 2025
Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, China, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Bispecific T-cell engagers (BiTEs) are small-molecule antibodies that exhibits potent tumoricidal activity but suffer from a short plasma half-life. Mesenchymal stromal cells (MSCs) represent promising delivery vehicles for sustained therapeutic protein expression. In this study, we used human umbilical cord blood-MSCs (hUC-MSCs) as a delivery system to to secrete HER2/CD3 BiTE antibodies, thereby addressing the pharmacokinetic limitations of conventional BiTE therapies.
View Article and Find Full Text PDFProteogenomic Analysis Identifies Clinically Relevant Subgroups of Collecting Duct Carcinoma.
Research (Wash D C)
September 2025
Department of Urology, Fudan University Shanghai Cancer Center, State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Human Phenome Institute, Fudan University, Shanghai 200433, China.
Collecting duct carcinoma (CDC) is a rare but aggressive form of renal cell carcinoma (RCC) that has limited understanding and an undefined systemic therapeutic regimen. Herein, we conducted a comprehensive proteogenomic analysis of CDC tumors and normal adjacent tissues to elucidate the biology of the disease. CDC exhibited high heterogeneity in tumor mutational burden, and enhanced ribosome biogenesis was the most striking malignant feature of CDC, even compared with other common kidney carcinomas.
View Article and Find Full Text PDFSEE-phAST: Spatially encapsulated emulsions for phenotypic antibiotic susceptibility testing via sequential digital RAA-CRISPR.
Biosens Bioelectron
August 2025
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325000, China; Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 1
The escalating threat of antimicrobial resistance is exacerbated by delayed diagnostics and improper antibiotics use, underscoring an urgent demand for rapid, versatile AST tools to support evidence-based prescribing. In this study, we present an innovative, generalizable phenotypic AST approach by quantifying bacterial gDNA copy number variations (CNVs) following 0.5-h-brief culturing with antibiotic exposure, termed spatially encapsulated emulsions (SEE)-phAST.
View Article and Find Full Text PDFEnzyme-linked immunosorbent STI assays: development, current status and future perspective.
J Microbiol Immunol Infect
August 2025
Department of Medical Laboratory and Regenerative Medicine, MacKay Medical University, New Taipei City, Taiwan; Research Institute for Science and Engineering, Waseda University, Japan; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan. Elect
Sexually transmitted infections (STIs) continue to pose major public health challenges globally, with millions of new cases reported annually. The asymptomatic characteristic of many STIs makes accurate and cost-effective diagnostic methods essential for screening and diagnosis. This paper evaluates the utility of enzyme-linked immunosorbent assays (ELISAs) in diagnoses of HIV, HPV, HSV, HBV, HCV, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and Treponema pallidum.
View Article and Find Full Text PDFPerforming SABER-FISH on Chromosome Spreads in Fixed Tissue Culture Cells and in Tissues.
Methods Mol Biol
August 2025
Department of Genome Sciences, University of Washington, Seattle, WA, USA.
Fluorescence in situ hybridization (FISH) visualizes targeted nucleic acid sequences in fixed samples, imparting information about target location and abundance. By itself, targets are limited to large regions or those with high copy number due to low fluorescent signal, motivating a need for signal amplification methods. In this chapter, we detail signal amplification by exchange reaction (SABER), a recent advancement in FISH technology that incorporates long, repetitive concatemers into FISH probes to recruit complementary fluorescent probes.
View Article and Find Full Text PDF