98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1111/his.15163 | DOI Listing |
Int J Surg Pathol
September 2025
Department of Pathology, Tata Memorial Hospital & Advanced Centre for Treatment and Research, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
Undifferentiated carcinomas with osteoclast-like giant cells of the pancreaticobiliary tract (UCOGCs) are rare but distinctive tumors with limited literature. To study the clinicopathologic characteristics of UCOGCs including morphology, immunohistochemistry (IHC), management, and survival outcomes. Assessment of 12 patients of UCOGC found over 10 years from a tertiary care oncology center database.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York City, NY, United States.
Introduction: Thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-dUT) is a recently described type of lung cancer, presenting as a bulky mass variably involving the mediastinum and the lung in patients with smoking history, and exhibits adverse prognosis. The essential diagnostic immunomorphologic features and typical genomic findings have been described. However, there is a continuing need to catalogue the spectrum of genomic changes underlying the disease, the heterogeneity of antigen expression in order to avoid diagnostic pitfalls, and any variability in patient outcomes.
View Article and Find Full Text PDFWorld J Gastroenterol
August 2025
Department of Pathology, Seoul National University Bundang Hospital, Seongnam-si 13620, Gyeonggi-do, South Korea.
Background: Poorly cohesive gastric carcinomas are classified based on the proportion of signet-ring cell carcinoma (SRCC) components. In surgically resected gastric cancer, SRCC is diagnosed when the signet-ring cell (SRC) component constitutes ≥ 50% of the entire tumor, whereas poorly cohesive carcinoma (PCC) not otherwise specified is diagnosed when the proportion of the SRC component is < 50% of the entire tumor. The SRCC proportion in PCC varies along the spectrum, and its prognostic significance in gastric cancer remains unclear.
View Article and Find Full Text PDFThorac Cancer
September 2025
Yokohama City Minato Red Cross Hospital, Pathology, Yokohama, Kanagawa, Japan.
Chest wall sarcomas are rare and may exhibit aggressive behavior, posing diagnostic challenges-particularly in young adults. Although multidisciplinary treatments involving chemotherapy, radiotherapy, and surgery are recommended, prognosis remains poor. We report a case of a 43-year-old man referred with left-sided chest pain, dyspnea, and massive pleural effusion.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Key Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing, China.
Rationale: Large cell lung carcinoma (LCLC) is a rare undifferentiated malignant epithelial tumor of the lung. The diagnostic complexity of LCLC stems from its pronounced histological heterogeneity and diverse clinical presentation, particularly when extrapulmonary manifestations constitute the initial disease presentation, complicating early detection.
Patient Concerns: A 58-year-old smoker presented with acute-onset dizziness, lethargy, and communication difficulties lasting 1 day.