Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
is a plant that grows in salty regions along the coastline and exerts radical-scavenging and anti-inflammatory effects. In this study, we investigated the skin-whitening effects of extract (SME) in B16F10 melanoma cells. SME was found to exert radical-scavenging effects. It suppressed α-melanocyte-stimulating hormone-induced melanogenesis and tyrosinase activity. We also assessed the melanin production signaling pathway to identify the inhibitory action mechanism of SME on melanogenesis. SME decreased the protein expression levels of tyrosinase-related protein (TRP)-1, TRP-2, and tyrosinase, which play important roles in melanogenesis. Furthermore, western blotting revealed that SME inhibited the nuclear translocation of melanocyte inducing transcription factor (MITF), which is a transcription factor for TRP-1, TRP-2, and tyrosinase, suggesting that SME exerts its skin-whitening effect by inhibiting MITF nuclear translocation. Therefore, SME may potentially be used in skin-whitening medicines and cosmetics.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10866852 | PMC |
| http://dx.doi.org/10.1007/s10068-023-01376-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Discovery of Potential Tyrosinase Inhibitors via Machine Learning and Molecular Docking with Experimental Validation of Activity and Skin Permeation.
ACS Omega
September 2025
Centre of Artificial Intelligence Driven Drug Discovery, Faculty of Applied Science, Macao Polytechnic University, Macao SAR 999078, China.
Tyrosinase, a copper-dependent oxidase, plays a critical role in melanin biosynthesis and is a target in skin-whitening cosmetics. Conventional inhibitors like arbutin and kojic acid are widely used but suffer from cytotoxicity, instability, and inconsistent efficacy, highlighting the need for safer, more effective alternatives. In this study, two ligand-based machine learning models were developed: one to predict the biological activity of compounds and the other to estimate specific pIC values.
View Article and Find Full Text PDFA novel sandwich-type fluorescent sensor for the selective and sensitive detection of ellagic acid based on boronate affinity oriented imprinting and silver nanoparticle-enhanced fluorescence of boronic acid-modified CdTe quantum dots.
Food Chem
August 2025
School of Chemistry and Chemical Engineering, Anhui University of Technology, Maanshan 243032, PR China; Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology, Yulin Normal University, Yulin 537000, China. Electronic address:
Ellagic acid (EA) exhibits remarkable in-vivo bioactivity and antioxidant properties. EA is also a skin-whitening agent. Accurate quantification of EA is crucial for the effective use of EA-rich foods and cosmetics.
View Article and Find Full Text PDFComprehensive Evaluation of the Safety and Efficacy of MOSY PHYCOLLREPAIR: A Novel Fermented Black Bee Honey-Derived Cosmetic Ingredient.
J Cosmet Dermatol
August 2025
Vitargent (International) Biotechnology Limited, Hong Kong, SAR, China.
Background: MOSY PHYCOLLREPAIR is an innovative cosmetic ingredient extracted from fermented blank bee honey, specifically engineered for dermatological applications.
Objective: This study seeks to thoroughly evaluate the safety and diverse efficacy profiles of MOSY PHYCOLLREPAIR within cosmetic formulations.
Methods: The safety of MOSY PHYCOLLREPAIR was determined through zebrafish embryo developmental toxicity assays.
Enhanced tyrosinase inhibitory activity of side chain-modified aromatic-turmerone derived from Curcuma longa for advanced skin whitening formulations.
Int J Biol Macromol
September 2025
Department of Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia; Suzhou Industrial Park Monash Research Institute of Science and Technology, Monash University, SIP, Suzhou 215000, PR China. Electronic address:
Tyrosinase (TYR) is a key enzyme in melanin production and a crucial target for skin-whitening agents. Due to challenges in isolating pure human TYR, we constructed a homology model and evaluated the inhibitory effects of Ar-turmerone (A1) and its derivatives (A8 and B18) through in vitro assays and molecular dynamics (MD) simulations. Ar-turmerone reduced TYR activity by 19.
View Article and Find Full Text PDFSeaweed-derived bioactives with anti-tyrosinase activity: a potential for skin-whitening cosmetics with and approaches.
Biotechnol Rep (Amst)
September 2025
Department of Biotechnology, Faculty of Science and Technology, Thammasat University, Rangsit Center, Pathum Thani 12121, Thailand.
Seaweed is a promising source of bioactive compounds with potential applications in skincare, particularly for addressing hyperpigmentation. This study investigated the chemical profiles and biological activities of hydrophilic and lipophilic extracts from , and . LC-MS and GC-MS analyses identified 8 and 112 compounds in hydrophilic and lipophilic extracts, respectively.
View Article and Find Full Text PDF