Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determinants in 85 genetically diverse recombinant intercross advanced inbred lines (RIAILs). We assessed molecular profiles - transcriptome, proteome, and lipidome - and life-history traits, including lifespan, development, growth dynamics, and reproduction. RIAILs exhibited large variations in lifespan, which positively correlated with developmental time. Among the top candidates obtained from multi-omics data integration and QTL mapping, we validated known and novel longevity modulators, including , and . We translated their relevance to humans using UK Biobank data and showed that variants in and are associated with an elevated risk of age-related heart disease, dementia, diabetes, kidney, and liver diseases. We organized our dataset as a resource (https://lisp-lms.shinyapps.io/RIAILs/) that allows interactive explorations for new longevity targets.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827074 | PMC |
| http://dx.doi.org/10.1101/2024.01.15.575638 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Controlling collagen I orientation on polyetheretherketone implants to improve epithelial sealing.
ACS Biomater Sci Eng
September 2025
Materials Engineering, McGill university, Montreal H3A0C5, Canada.
Transcutaneous devices such as dental implants frequently fail due to infections at their interfaces with epithelial tissues. These infections are facilitated by the lack of integration between the devices and the surrounding soft tissues. This study aims to improve epithelial integration through surface modification of a transcutaneous implant material (polyetheretherketone (PEEK)).
View Article and Find Full Text PDFCharacterization of Cross-Linked Elastomer Networks by Thermal Desorption/Pyrolysis Direct Analysis in Real-Time Mass Spectrometry (TDPy-DART-MS).
Anal Chem
September 2025
Department of Chemistry, The University of Akron, Akron, Ohio 44325, United States.
Tires are complex polymeric materials composed of rubber elastomers (both natural and synthetic), fillers, steel wire, textiles, and a range of antioxidant and curing systems. These constituents are distributed differently among the various tire parts, which are classified based on their function and proximity to the rim. This study presents a rapid and sensitive approach for the characterization of tire components using mild thermal desorption/pyrolysis (TDPy) coupled to direct analysis in real-time mass spectrometry (DART-MS).
View Article and Find Full Text PDFThe Essence of Nature Can be the Simplest (6)-Lifespan: Determined by Extracellular Fenton Chemistry.
Chem Biodivers
September 2025
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan & Yunnan Key Laboratory of Basic Research and Innovative Application for Green Biological Production, Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Sciences, Yunnan University, Kunm
Understanding the determinants of lifespan is a central objective in biology. Lifespan is shaped by dynamic, stage-specific changes in metabolism, energy allocation, and genome integrity. Heart rate serves as a physiological marker that reflects both life stage and metabolic state.
View Article and Find Full Text PDFEstrogen therapy in patients with gynecologic cancer: a survey of gynecologists and oncologists in the United States.
Menopause
September 2025
Department of Gynecologic Oncology, Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY.
Objective: Endometrial cancer (EC) and epithelial ovarian cancer (EOC) affect women of all ages, and the incidence of endometrial cancer in premenopausal women is rising. Menopause can be detrimental to longevity and quality of life, but evidence suggests estrogen therapy (ET) is safe in these patients. The purpose of this study was to evaluate the practice patterns of gynecologists and gynecologic oncologists (GYO) in the United States in regards to prescription of ET to gynecologic cancer patients.
View Article and Find Full Text PDFShrinking to bird size with dinosaur-level cancer defences: Evolution of cancer suppression over macroevolutionary time.
PLoS Comput Biol
September 2025
Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.
Ubiquity of cancer across the tree of life yields opportunities to understand variation in cancer defences across species. Peto's paradox, the finding that large-bodied species do not suffer from more cancer despite having more cells at risk of oncogenic mutations compared to small species, can be explained if large size selects for better cancer defences. Since birds live longer than non-flying mammals of equivalent size, and are descendants of moderate-sized dinosaurs, we ask whether ancestral cancer defences are retained if body size shrinks in a lineage.
View Article and Find Full Text PDF