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Article Abstract
pv. () is a significant pathogenic bacterium affecting the kiwifruit industry. This study investigated the target sites of streptothricin-F (ST-F), produced by gCLA4. The inhibition of ST-F on was examined by the microscopic structural differences of before and after treatment with ST-F, as well as the interaction between ST-F and cell division-related proteins. The results revealed filamentation of after ST-F treatment, and fluorescence microscopy showed that ST-F inhibited the formation of the Z-ring composed of FtsZ protein. In vitro experiments and molecular docking demonstrated that ST-F can bind to FtsZ with a binding energy of 0.4 μM and inhibit FtsZ's GTP-dependent polymerization reaction. In addition, ST-F does not exert inhibitory effects on cell division in strains overexpressing . In conclusion, FtsZ is one of the target sites for ST-F inhibition of , highlighting its potential as a therapeutic target for controlling -induced kiwifruit bacterial canker.
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