Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Myocardial recovery occurs in patients with advanced heart failure on left ventricular assist device (LVAD) support, but there is the premise that it is rare with uncertain results.
Objectives: The goal of this study was to investigate the incidence and consequence of LVAD explant after myocardial recovery.
Methods: Using the United Network for Organ Sharing registry, LVAD implants in the United States between 2005 and 2020 were tracked until death, transplantation, or explant for myocardial recovery. The cohort undergoing explant was followed up for heart failure relapse (defined as relisting followed by delisting due to death, being too ill, or transplantation; or second durable LVAD implant).
Results: Of 15,728 LVAD implants, 126 patients underwent explant for recovery, which only occurred in 55 (38%) of 145 implanting centers. The crude cumulative incidence was 0.7% at 2 years, whereas the incidence reached 4.7% among designated centers in the selected young nonischemic cohort. Of 126 explanted patients, 76 (60%) were subsequently delisted for sustained recovery. Heart failure relapsing had a relatively higher hazard in the early phase, with a 30-day incidence of 6% (7 of 126) but tapered following with the freedom rate of 72.5% at 4 years.
Conclusions: In the United States, LVAD explant for myocardial recovery was underutilized, leading to a very low incidence at the national level despite a realistic rate being achieved in designated centers for selected patients. With follow-up extending up to 4 years after explant, more than one-half were successfully removed and stayed off the waitlist, and approximately 70% were free from heart failure relapse events.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jchf.2023.12.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reperfusion injury in STEMI: a double-edged sword.
Egypt Heart J
September 2025
Department of Medicine, Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia.
Background: ST-elevation myocardial infarction (STEMI) is a major cardiac event that requires rapid reperfusion therapy. The same reperfusion mechanism that minimizes infarct size and mortality may paradoxically exacerbate further cardiac damage-a condition known as reperfusion injury. Oxidative stress, calcium excess, mitochondrial malfunction, and programmed cell death mechanisms make myocardial dysfunction worse.
View Article and Find Full Text PDFDiagnostic and Prognostic Significance of Exercise Stress Testing in Desmosomal Arrhythmogenic Cardiomyopathy.
JACC Clin Electrophysiol
August 2025
Department of Cardiovascular Medicine, Division of Heart Rhythm Services and the Windland Smith Rice Genetic Heart Rhythm Clinic, Mayo Clinic, Rochester, Minnesota, USA; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Cardiac Death Genomics Laboratory,
Background: Arrhythmogenic cardiomyopathy (ACM) is characterized by fibrofatty myocardial replacement and increased arrhythmic risk. Although exercise exacerbates desmosomal ACM, the prognostic significance of arrhythmias during exercise stress tests (ESTs) remains unclear.
Objectives: The goal of this study was to determine the impact of ventricular arrhythmia observed during peak exercise and/or recovery EST phases on the risk of major ventricular arrhythmia (MVA) events in patients with desmosomal ACM.
Cardiovascular dysfunction significantly contributes to morbidity and mortality following cervical spinal cord injury (SCI). Unfortunately, only a limited number of preclinical models have been developed for investigating cardiovascular dysfunction following cervical SCI. Furthermore, the broader consequences of cervical SCI on aerobic capacity and muscle endurance during physiological stress testing also remains understudied preclinically.
View Article and Find Full Text PDFRescue of acute ST-elevation myocardial infarction secondary to traumatic coronary artery rupture: a case report.
Eur Heart J Case Rep
September 2025
Department of Emergency, Xiamen Cardiovascular Hospital, Xiamen University, No. 2999 Jinshan Road, Huli District, Xiamen, China 361000.
Background: Trauma-related acute myocardial infarction represents a complex and high-risk condition in the emergency department, necessitating a range of sophisticated treatment strategies. Failure to provide timely and accurate intervention significantly increases the risk of short-term mortality.
Case Summary: We present the case of a 36-year-old male who was admitted to local hospital following a penetrating chest trauma.
Rapid free-breathing myocardial T mapping with free-running interleaved multi-slice acquisition and respiratory motion correction using self-navigated auto calibration.
Magn Reson Med
September 2025
School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China.
Purpose: To develop a rapid 2D free-running myocardial mapping technique that is robust to through-plane respiratory motion.
Methods: A free-running golden angle radial sequence consisting of encoding and self-navigated auto motion calibration (SNAC) was developed. The encoding adopted inversion recovery (IR) prepared interleaved multi-slice acquisition with optimized inter-slice gap to ensure a uniform excitation of the middle slice regardless of through-plane respiratory motion.