Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Herein, we report a metal-free and efficient method for the C(sp)-H functionalization of 1,2,3,4-tetrahydroacridines at the C4-position by the addition of azodicarboxylates (C-N bond) and maleimides (C-C bond) using deep eutectic solvents (DESs) at 80 °C. The C4-functionalized 1,2,3,4-tetrahydroacridines were achieved with high atom efficiency, precise regioselectivity, and yields ranging from 70-96%. The practicality of the developed method has been demonstrated through gram-scale synthesis. Also the green-metrics were calculated for the developed method and it was found that the metrics are near to the ideal values.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d3ob01752d | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Alkali metal hydroxide-catalyzed mechanisms of Csp-H silylation of alkynes: a DFT investigation.
Org Biomol Chem
August 2024
Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong, China.
Mechanisms for the Csp-H silylation between prop-2-yn-1-ylcyclohexane and triethylsilane, catalyzed by MOH/MH (M = Na or K), were investigated at the M06-L-D3/ma-def2-TZVP level. The SMD model was applied to simulate the solvent effect of 1,2-dimethoxyethane (DME). Computational results suggested that the Csp-H activation of prop-2-yn-1-ylcyclohexane could be achieved by MOH to generate R-CC-M compounds, which continued to react with triethylsilane to yield the final product: (3-cyclohexylprop-1-yn-1-yl) triethylsilane.
View Article and Find Full Text PDFRecent progress in the oxidative coupling of unactivated Csp-H bonds with other C-H bonds.
Chem Commun (Camb)
December 2021
Department of Chemistry, Fudan University, 2005 Songhu Rd, Shanghai, 200438, China.
Article Synopsis
- - The article discusses the oxidative coupling of carbon-hydrogen (C-H) bonds as a simple and efficient way to create carbon-carbon (C-C) bonds from hydrocarbons without needing any prior modifications.
- - It highlights recent advancements in coupling unactivated Csp-H bonds with various hybrid C-H bonds, including combinations with Csp-H bonds.
- - The paper provides a summary of the types of substrates used, proposed reaction mechanisms, and potential applications, aiming to inspire new methods for building Csp-C bonds effectively.
Electrophysiological findings in patients with restless legs syndrome.
Sleep Med
November 2021
Department of Physiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq. Electronic address:
Background: Restless legs syndrome (RLS) manifests as an urge to move the body to relieve the discomfortable sensations, primarily when resting, sitting, laying down, or sleeping. Diagnosis of RLS relies on clinical criteria, and the immobilization test was the only instrumental tool with equivocal results.
Objectives: To assess different electrophysiological findings in patients with RLS, and compare the diagnostic values of these parameters in the diagnosis of RLS.
Development of amplicon deep sequencing markers and data analysis pipeline for genotyping multi-clonal malaria infections.
BMC Genomics
November 2017
Swiss Tropical and Public Health Institute, Basel, Switzerland.
Background: Amplicon deep sequencing permits sensitive detection of minority clones and improves discriminatory power for genotyping multi-clone Plasmodium falciparum infections. New amplicon sequencing and data analysis protocols are needed for genotyping in epidemiological studies and drug efficacy trials of P. falciparum.
View Article and Find Full Text PDFNervous system excitability and joint stiffness following short-term dynamic ankle immobilization.
Gait Posture
January 2018
Department of Health & Exercise Science, Appalachian State University, Boone, NC, USA. Electronic address:
Article Synopsis
- Joint immobilization can alter neural excitability but most studies focus on rigid methods, while real-world injuries often use dynamic devices like boots and splints.
- This study tested 12 healthy individuals to see if walking in different ankle immobilization devices affects neural excitability and stiffness.
- Results showed no significant changes in cortical excitability, reflexive excitability, or ankle stiffness after 30 minutes of ambulation, suggesting that any changes in neural excitability seen in previous studies are likely due to long-term adaptations rather than immediate effects.