98%
921
2 minutes
20
A remarkable feature of two-dimensional turbulence is the transfer of energy from small to large scales. This process can result in the self-organization of the flow into large, coherent structures due to energy condensation at the largest scales. We investigate the formation of this condensate in a quasigeostropic flow in the limit of small Rossby deformation radius, namely the large-scale quasigeostrophic model. In this model potential energy is transferred up-scale while kinetic energy is transferred down-scale in a direct cascade. We focus on a jet mean flow and carry out a thorough investigation of the second-order statistics for this flow, combining a quasilinear analytical approach with direct numerical simulations. We show that the quasilinear approach applies in regions where jets are strong and is able to capture all second-order correlators in that region, including those related to the kinetic energy. This is a consequence of the blocking of the direct cascade by the mean flow in jet regions, suppressing fluctuation-fluctuation interactions. The suppression of the direct cascade is demonstrated using a local coarse-graining approach allowing us to measure space dependent interscale kinetic energy fluxes, which we show are concentrated in between jets in our simulations. We comment on the possibility of a similar direct cascade arrest in other two-dimensional flows, arguing that it is a special feature of flows in which the fluid element interactions are local in space.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1103/PhysRevE.108.065102 | DOI Listing |
J Enzyme Inhib Med Chem
December 2025
Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, India.
The mitogen-activated protein kinase (MAPK) pathway-also known as the RAS/RAF/MEK/ERK pathway-is a critical signalling cascade involved in regulating cell growth, proliferation, and survival. First discovered in the early 1980s, the pathway's extracellular signal-regulated kinase (ERK) subfamily was identified in the 1990s. The ERK family includes several isoforms-ERK1, ERK2, ERK3, ERK5, and ERK6-with ERK1 (MAPK3) and ERK2 (MAPK1) being the most well-characterised and playing central roles in MAPK signalling.
View Article and Find Full Text PDFMater Today Bio
October 2025
Yunnan Key Laboratory of Breast Cancer Precision Medicine, Institute of Biomedical Engineering, Kunming Medical University, Kunming, 650500, Yunnan, China.
Achieving precise intratumoral accumulation and coordinated activation remains a major challenge in nanomedicine. Photothermal therapy (PTT) provides spatiotemporal control, yet its efficacy is hindered by heterogeneous distribution of PTT agents and limited synergy with other modalities. Here, we develop a dual-activation nanoplatform (IrO-P) that integrates exogenous photothermal stimulation with endogenous tumor microenvironment (TME)-responsive catalysis for synergistic chemodynamic therapy (CDT) and ferroptosis induction.
View Article and Find Full Text PDFJ Therm Biol
September 2025
Department of Critical Care Medicine, the First Medical Cener, Chinese PLA General Hospital, Beijing, 100853, China. Electronic address:
Heat stroke (HS), a life-threatening heat-related disorder, is characterized by a rapid elevation of core body temperature exceeding 40 °C, accompanied by central nervous system (CNS) dysfunction and multiple organ dysfunction syndrome (MODS). With the escalating impact of global warming, the incidence of HS has risen progressively, posing a significant threat to global health. The CNS is one of the primary target organs in HS, and its injury mechanisms involve intricate interactions among inflammatory cascades, oxidative stress, programmed cell death, and blood-brain barrier (BBB) disruption.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
Department of Spine Surgery, The 3rd Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, P. R. China.
Fibrotic scarring remains a critic obstacle to axonal regeneration after spinal cord injury (SCI). Current strategies primarily concentrating on eliminating extracellular matrix (ECM) components neglect their dispensable roles in maintaining tissue integrity. Here, it is reported that the mechanical strength of an integrated hydrogel composed of hyaluronic acid-graft-dopamine and HRR peptide directs fibroblast migration, determining ECM deposition.
View Article and Find Full Text PDFJ Integr Neurosci
August 2025
Department of Neurobiology, Hebei Medical University, 050017 Shijiazhuang, Hebei, China.
Background: Sodium homeostasis is crucial for physiological balance, yet the neurobiological mechanisms underlying sodium appetite remain incompletely understood. The nucleus tractus solitarii (NTS) integrates visceral signals to regulate feeding behaviors, including sodium intake. This study investigated the role of 11β-hydroxysteroid dehydrogenase type 2 (HSD2)-expressing neurons in the NTS in mediating sodium appetite under low-sodium diet (LSD) conditions and elucidated the molecular pathways involved, particularly the cyclic adenosine monophosphate (cAMP)/mitogen-activated protein kinase (MAPK) signaling cascade.
View Article and Find Full Text PDF