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http://dx.doi.org/10.3389/fchem.2023.1355870 | DOI Listing |
Elife
September 2025
Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland.
An atlas of all the cell types in the dorsal vagal complex of rodents will help neuroscientists seeking to understand appetite and researchers working to design better drugs for the treatment of obesity and related disorders.
View Article and Find Full Text PDFJ Transl Med
September 2025
Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Bologna, BO, Italy.
Endogenous transposable elements (TEs) are receiving increasing attention as potential targets to develop novel immunostimulatory strategies against cancer. Indeed, the defective epigenetic suppression of TEs in malignant cells offers a therapeutic window to enable their re-activation with at least some degree of selectivity. In line with this notion, multiple clinically employed epigenetic modifiers such as DNA-demethylating agents have been shown to promote the re-expression of TEs in preclinical tumour models, hence driving powerful inflammatory responses that enables increased sensitivity of immunitary immune cells to immunotherapy with immune checkpoint inhibitors (ICIs).
View Article and Find Full Text PDFExplor Neuroprotective Ther
May 2025
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA.
Neurodegenerative diseases represent a significant and growing challenge to public health worldwide. Current therapeutic strategies often fall short in halting or reversing disease progression, highlighting the urgent need for novel approaches. Extracellular vesicles (EVs) have garnered attention as potential therapeutic agents due to their role in intercellular communication and their ability to transport bioactive cargo, including proteins, nucleic acids, and lipids.
View Article and Find Full Text PDFGenome Biol
August 2025
Plant Molecular and Cellular Biology Program, University of Florida, Gainesville, FL, USA.
Background: Single-cell genomics is revolutionizing plant developmental biology, enabling the transcriptome profiling of individual cells and their lineage relationships. However, plant cell walls polymers hamper the dissociation and analysis of intact cells. This rigid structure can conceal cell types embedded in complex, lignified, multi-cell layered tissues such as those undergoing secondary growth.
View Article and Find Full Text PDFNucleic Acids Res
August 2025
UT Southwestern Medical Center, Department of Pharmacology and Biochemistry, 6001 Forest Park Road, Dallas TX 75390, United States.
The action of microRNAs (miRNAs) in mammalian cells involves recognition of messenger RNA (mRNA) in the cytoplasm and inhibition of translation. Both miRNAs and their associated protein factors, however, are present in mammalian cell nuclei. It is unclear how this nuclear localization affects endogenous gene expression.
View Article and Find Full Text PDF