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Association between myopia and relative peripheral refraction in children with monocular Tilted disc syndrome.

BMC Ophthalmol

May 2025

Department of Ophthalmology, The Second Hospital of Hebei Medical University, No. 215, West Heping Road, Shijiazhuang City, 050000, Hebei Province, People's Republic of China.

Background: This study aimed to investigate the refractive error and relative peripheral refraction in pediatric patients with monocular tilted disc syndrome.

Methods: This single-center, prospective, cross-sectional, observational study included 49 patients from the Pediatric Ophthalmology Department of the Second Hospital of Hebei Medical University aged 5-17 years with monocular tilted disc syndrome. Eyes with tilted optic discs formed the study group, and contralateral eyes with normal discs served as controls, with mean spherical equivalents of - 3.

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This study was aimed to investigate the influence of miR-33-5p on the M1/M2 polarization of microglia and the underlying mechanism. Transcriptome sequencing was performed using microglia from miR-33-5p mimic and control groups. In total, 507 differentially expressed genes, including 314 upregulated genes and 193 downregulated genes, were identified.

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Objective: To investigate the outcome of the rapid lowering of elevated blood pressure in patients with intracerebral hemorrhage and to understand its association with clinical outcome.

Materials And Methods: Between July 2014 and June 2018, a total of 1,500 patients diagnosed with cerebral hemorrhage were randomized and assessed for their neurological symptoms and diagnosed with CT scan. 1,500 (42%) patients received intensive treatment, while 1,645 (58%) patients were assigned the guideline-recommended therapy.

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Glioblastoma multiforme (GBM) is one of the most lethal and damaging types of human cancer. The current study was conducted to identify differentially methylated genes (DMGs) between GBM and normal controls, and to improve our understanding of GBM at the epigenetic level. The DNA methylation profile of GBM was downloaded from the Gene Expression Omnibus (GEO) database using the accession number GSE50923.

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Background: Integration of several types of therapeutic agents into one nanoplatform to enhance treatment efficacy is being more widely used for cancer therapy.

Methods: Herein, a biocompatible polydopamine (PDA)-coated MoSe-wrapped doxorubicin (DOX)-loaded hollow mesoporous silica nanoparticles (HMSNs) nanoplatform (PM@HMSNs-DOX) was fabricated for dual-sensitive drug release and chemo-photothermal therapy for enhancing the therapeutic effects on breast cancer. The HMSNs were obtained by a "structural difference-based selective etching" strategy and served as the drug carrier, exhibiting a high DOX loading capacity of 427 mg/g HMSNs-NH, and then wrapped with PDA-coated MoSe layer to form PM@HMSNs-DOX.

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