Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Coupling of photoswitching with dynamic covalent chemistry enables control of the formation and cleavage of covalent bonds by light irradiation. -Aryloxyanthraquinones feature an exclusive ability to switch electrophilicity by interconversion between - and -quinone isomers, which was used for the first time for the implementation of a dynamic C-O bond. Photogenerated -isomers undergo a concerted -Michael addition of phenols to give hitherto unknown 4-hydroxy-10,10-diaryloxyanthracen-9-ones. These species were found to be in equilibrium with the corresponding -quinones, thus forming a dynamic covalent system of a new type. Withdrawal of the colored -quinones from the equilibria by visible light irradiation resulted in two -quinones with "locked" aryloxy groups.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jacs.3c12461 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
RNA G-quadruplexes emerge from a compacted coil-like ensemble via multiple pathways.
Nucleic Acids Res
September 2025
Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, Brno 61200, Czech Republic.
RNA G-quadruplexes (rG4s) are emerging as vital structural elements involved in processes like gene regulation, translation, and genome stability. Found in untranslated regions of messenger RNAs (mRNAs), they influence translation efficiency and mRNA localization. Additionally, rG4s of long noncoding RNAs and telomeric RNA play roles in RNA processing and cellular aging.
View Article and Find Full Text PDFThe advantage of periodic over constant signalling in microRNA-mediated regulation.
Nucleic Acids Res
September 2025
Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
Cells may exploit oscillatory gene expression to encode biological information. Temporal features of oscillations, such as pulse frequency and amplitude, are determinant for the outcome of signalling pathways. However, little effort has been devoted to unveiling the role of pulsatility in the context of post-transcriptional gene regulation, where microRNAs act by binding to RNAs and regulate their expression.
View Article and Find Full Text PDFReactive Evolution of HMML from Gas Phase Formation to Interface Transformation on Sulfuric Acid Aerosols: A Multiscale Computational Study.
J Phys Chem A
September 2025
School of Environmental Engineering, Henan University of Technology, Zhengzhou, Henan 450001, China.
Hydroxymethyl-methyl-α-lactone (HMML) is a key epoxide precursor in forming tracer compounds 2-methylglyceric acid (2-MG) or 2-methylglyceric acid sulfate (2-MGOS) from isoprene under high-NOx conditions. Despite its importance, the formation and transformation of HMML─particularly under acidic aerosol conditions─are still poorly understood, limiting comprehensive knowledge of secondary organic aerosol (SOA) formation. In this study, quantum chemical calculations, Born-Oppenheimer molecular dynamics (BOMD), and metadynamics (MTD) simulations are employed to investigate both the formation of HMML from methacryloyl peroxynitrate (MPAN) and its interfacial transformation mechanisms on sulfuric acid aerosols.
View Article and Find Full Text PDFThe Antimicrobial Activity of Silver Nanoparticles Biosynthesized Using Against Multidrug-Resistant Bacteria Isolated from an Intensive Care Unit.
Pharmaceuticals (Basel)
July 2025
Multi-User Laboratory, Postgraduate Program in Environment and Health, Planalto Catarinense University, Lages 88509-900, SC, Brazil.
This study aimed to evaluate the in vitro efficacy of silver nanoparticles (AgNPs) synthesized by bioreduction using lemongrass () essential oil against multidrug-resistant (MDR) bacteria isolated from an Intensive Care Unit (ICU). The essential oil was extracted and characterized by gas chromatography-mass spectrometry (GC-MS). Antioxidant activity was assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, the 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay, and total phenolic content.
View Article and Find Full Text PDFThe regulatory role of oxidative stress in the tooth movement process of rats with chronic fluorosis.
BMC Oral Health
August 2025
Department of Stomatology, Guizhou Provincial People's Hospital, Guiyang, 550000, China.
Background: Clinically, fluorosis patients exhibit delayed orthodontic tooth movement and compromised retention. Experimental studies in fluorosis-exposed rats demonstrate suppressed tooth movement, impaired periodontal angiogenesis, and downregulated VEGF/PI3K/AKT/eNOS signaling. Oxidative stress is critical in periodontal remodeling during orthodontic treatment, yet its role in fluorosis-related movement alterations remains unclear.
View Article and Find Full Text PDF