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Drawing upon information entropy theory, this study deduces a measurement formula for the information entropy for key audit matters (KAMs) disclosure, considering both system scale and audit report scale. The information entropy of an audit report within a specific system is calculated as the weighted average logarithm value of the continuous product of KAM disclosure frequencies. Subsequently, a systematic calculation of KAM disclosure information entropy is conducted using 14,837 financial statement audit reports from listed companies traded on the Shanghai and Shenzhen Stock Exchanges, covering the FY 2017-20 period. The findings indicate that: (1) The information entropy of KAM disclosure has decreased from 2017 to 2020, while the homogenization degree of KAM disclosure has increased. (2) The information entropy and evenness of KAM disclosure on the main board are significantly higher than those of the ChiNext and the STAR Market. (3) The transportation, storage and postal services, manufacturing, finance, power supply, heating, gas and water supply industries exhibit the highest overall information entropy of KAM disclosure, indicating good quality. (4) The information entropy and evenness of KAM disclosure are higher for the big 4 accounting firms compared to domestic accounting firms and big 8 accounting firms. (5) The KAMs disclosed when the Certified Public Accountant (CPA) provides unqualified opinions, emphasizing that matter paragraphs possess higher information value, and are more disorderly and balanced. The measurement method and related results of information entropy offer reference and comparative value for future research on the quality of KAMs disclosure.
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http://dx.doi.org/10.1016/j.heliyon.2023.e23255 | DOI Listing |
J Thorac Oncol
September 2025
Institut du Thorax Curie-Montsouris, Paris, France; Paris-Saclay University, UVSQ-Versailles, France.
Introduction: Amivantamab plus lazertinib significantly improved progression-free and overall survival versus osimertinib in patients with previously untreated, EGFR-mutant advanced NSCLC. EGFR-targeted therapies are associated with dermatologic adverse events (AEs), which can affect quality of life (QoL). COCOON was conducted to assess prophylactic management and improve treatment experience.
View Article and Find Full Text PDFJ Mol Diagn
August 2025
Foundation Medicine, Inc., Boston, Massachusetts.
This study evaluated a UV mutational signature classifier applied to circulating tumor DNA (ctDNA) in cell-free DNA liquid biopsies, using the FoundationOne Liquid CDx platform. Among 73,790 samples, 12.9% (9527) met the variant threshold for signature analysis, with UV signatures detected in 3.
View Article and Find Full Text PDFCurr Urol
July 2025
North Shore Urology Research Group, Sydney, Australia.
Objectives: To describe the surgical approach and perioperative outcomes of a multicenter series evaluating a robotic-assisted approach to radical cystectomy with total intracorporeal urinary diversion in the setting of prior pelvic radiotherapy.
Materials And Methods: We analyzed our prospective cystectomy database for patients who underwent robotic-assisted radical cystectomy for bladder cancer after radiotherapy between 2018 and 2022. Demographic information and data regarding preoperative factors including stage of disease, preoperative hydronephrosis, and history of pelvic radiotherapy were collected via review of electronic medical records.
Invest Ophthalmol Vis Sci
August 2025
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administration Region, China.
Purpose: The purpose of this study was to evaluate the associations of optic nerve head (ONH) metrics and parapapillary gamma zone with myopia onset and progression in school children aged 6 to 8 years over a 3-year period.
Methods: The ONH was imaged by spectral domain-optical coherence tomography (SD-OCT) using an adopted scan protocol comprising 24 equally spaced radial B-scans.
Results: The study included 765 children (mean age = 7.
Adv Healthc Mater
July 2025
Department of Biomedical Engineering, Department of Medicine, Columbia University, New York, 10027, USA.
Variability in T cell performance presents a major challenge to adoptive cellular immunotherapy (ACT). This includes expansion of a small starting population into therapeutically effective numbers, which can fail due to differences between individuals and disease states. Intriguingly, modulating the mechanical stiffness of materials used to activate T cells can rescue subsequent expansion.
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