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A case report of terbinafine-induced acute generalized exanthematous pustulosis in a striking photodistributed pattern.
SAGE Open Med Case Rep
February 2024
Department of Dermatology, Vanderbilt University Medical Center, Nashville, TN, USA.
Acute generalized exanthematous pustulosis is a rare severe cutaneous adverse reaction that classically presents in intertriginous or flexural areas and subsequently spreads diffusely across the trunk and extremities. To date, few cases of acute generalized exanthematous pustulosis arising in a photodistributed pattern are documented. Herein, we describe the second known case of photodistributed generalized exanthematous pustulosis arising in association with oral terbinafine use, providing a summary of the previously documented cases along with exploration of the potential pathophysiological mechanisms for this cutaneous reaction.
View Article and Find Full Text PDFTerbinafine-induced generalized pustular psoriasis (GPP) of von Zumbusch simulating toxic epidermal necrolysis (TEN).
J Dtsch Dermatol Ges
February 2024
Department of Dermatology & Skin Science, University of British Columbia, Vancouver, BC, Canada.
Terbinafine Induced Acute Generalized Exanthematous Pustulosis Treated with Adalimumab: Recalcitrant to Systemic Corticosteroid Therapy.
Clin Cosmet Investig Dermatol
January 2023
Department of Dermatology Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Article Synopsis
- Acute generalized exanthematous pustulosis (AGEP) is a skin condition often triggered by medications, presenting as rapid development of pustules on red skin, fever, and increased white blood cell counts.
- A case involving a 24-year-old female treated with terbinafine for nail fungus showed AGEP symptoms shortly after starting the medication, but her condition worsened despite stopping terbinafine and starting corticosteroids.
- Treatment with adalimumab was initiated, leading to symptom improvement, and this case highlights the rare interaction of terbinafine with AGEP unresponsive to corticosteroid treatment.
What to expect when AGEP is induced by terbinafine? Case report and critical review of the literature.
Mycoses
October 2022
Sector of Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Belo Horizonte, MG, Brazil.
Background: Acute Generalised Exanthematous Pustulosis (AGEP) is a rash with multiple sterile intraepidermal or subcorneal non-follicular pustules on edematous papules, with a sudden development and rapid evolution, triggered by drugs, vaccination, insect bites, exposure to mercury, and allergens.
Objectives And Methods: We describe a female patient who developed extensive and abnormally prolonged AGEP following exposure to terbinafine and SARS-CoV vaccine. A detailed review of terbinafine-induced-AGEP cases was performed, with the aim of evaluating if the AGEP criteria would follow a different pattern when the disease is triggered by this drug.
Republished: Concurrent terbinafine-induced acute generalised exanthematous pustulosis and hepatitis.
Drug Ther Bull
May 2022
Jackson Memorial Hospital, Miami, Florida, USA