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Study Design: Cross-sectional survey.
Objective: Currently there is limited evidence and guidance on the management of mild degenerative cervical myelopathy (DCM) and asymptomatic spinal cord compression (ASCC). Anecdotal evidence suggest variance in clinical practice. The objectives of this study were to assess current practice and to quantify the variability in clinical practice.
Methods: Spinal surgeons and some additional health professionals completed a web-based survey distributed by email to members of AO Spine and the Cervical Spine Research Society (CSRS) North American Society. Questions captured experience with DCM, frequency of DCM patient encounters, and standard of practice in the assessment of DCM. Further questions assessed the definition and management of mild DCM, and the management of ASCC.
Results: A total of 699 respondents, mostly surgeons, completed the survey. Every world region was represented in the responses. Half (50.1%, n = 359) had greater than 10 years of professional experience with DCM. For mild DCM, standardised follow-up for non-operative patients was reported by 488 respondents (69.5%). Follow-up included a heterogeneous mix of investigations, most often at 6-month intervals (32.9%, n = 158). There was some inconsistency regarding which clinical features would cause a surgeon to counsel a patient towards surgery. Practice for ASCC aligned closely with mild DCM. Finally, there were some contradictory definitions of mild DCM provided in the form of free text.
Conclusions: Professionals typically offer outpatient follow up for patients with mild DCM and/or asymptomatic ASCC. However, what this constitutes varies widely. Further research is needed to define best practice and support patient care.
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http://dx.doi.org/10.1038/s41393-023-00945-8 | DOI Listing |
Eur Heart J
September 2025
Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro IDIPHISA, Manuel de Falla, 2, Madrid 28222, Spain.
Genetic family screening following the detection of a pathogenic or likely pathogenic variant in a proband with dilated cardiomyopathy (DCM) remains one of the main applications of genetic testing. While cardiac screening is recommended for all first-degree relatives, the a priori risk among family members varies. Consequently, screening regimens should be tailored according to both genetic and clinical information at the individual and familial level.
View Article and Find Full Text PDFN Am Spine Soc J
September 2025
Department of Neurosurgery, College of Medicine, University of Kentucky, 780 Rose St William R. Williard, Lexington, Kentucky, 40536, United States.
Background Context: Degenerative cervical myelopathy (DCM) is characterized by spinal cord compression, which can present with limb weakness and numbness, loss of fine motor skills, gait disturbance, and bladder dysfunction. The modified Japanese Orthopedic Association (mJOA) and Graded Redefined Assessment of Strength, Sensibility, and Prehension Version Myelopathy (GRASSP-M) scores evaluate distinct aspects to assess the severity of upper and lower extremity dysfunction. Our study aims to develop an integrative, multidimensional Dexterity, Cutaneous, and Muscle (DCM-72) scoring system to provide a more comprehensive and objective evaluation of upper extremity functional impairment.
View Article and Find Full Text PDFJ Org Chem
August 2025
Chemistry Department, Moscow State University, Leninskie Gory, Building 1/3, Moscow 119991, Russian Federation.
A wide class of 3-hydroxyisoindolinones can be prepared from o-keto acids and both alkyl and aryl amines using PyBOP, PyBrOP, HATU, HBTU, and the like, under mild conditions, typically at 5-25 °C in DCM with EtN as base. Both EWG- and EDG-bearing o-keto acids have been studied and the yields range from 40% up to 90%. In some cases, the intermediate activated keto ester has been isolated in crystalline form.
View Article and Find Full Text PDFEur Heart J Cardiovasc Imaging
August 2025
Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
Aims: To investigate the distribution of myocardial fibrosis and patterns of tissue characteristics on cardiovascular magnetic resonance (CMR) between athletes with LV dilatation and mild DCM patients.
Methods And Results: We prospectively recruited male cyclists/triathletes aged ≥50y who undertook ≥10h/week of exercise for ≥15y along with age/sex-matched patients with non-ischaemic heart failure (HF). Participants underwent clinical assessment, 12-lead ECG, stress-perfusion CMR with fibrosis assessment and parametric tissue mapping.
Cardiovasc Res
August 2025
Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Aims: Truncating variations in the titin gene (TTNtv) are the most common genetic cause of dilated cardiomyopathy (DCM) and have been implicated in various arrhythmic and heart failure phenotypes. Nonetheless, predicting the pathogenicity of a distinct subtype of TTNtv, canonical splice-site variations (TTNcsv), remains challenging. Furthermore, the precise transcriptional and phenotypic consequences associated with TTNcsv remain unclear.
View Article and Find Full Text PDF