Quasi-soliton solution to the model of two-color optical waves in PT-symmetry structures.

Soliton propagation of laser radiation in various nonlinear media is of great importance because of its numerous applications. Active periodic structures with parity-time symmetry provide the possibility for the solitons generation due to the balance of energy gain and loss. In the present paper, we derive an approximate analytical soliton solution to a model of two-color laser radiation propagation in an active periodic structure.

Targeting the miR-96-5p/Cathepsin B Pathway to Alleviate Neuron-Derived Neuroinflammation in Alzheimer's Disease.

Alzheimer's disease (AD) is one of the leading causes of dementia in the elderly, and no effective treatment is currently available. Cathepsin B (CTSB) is involved in key pathological processes of AD, but the underlying mechanisms and its relevance to AD diagnosis and treatment remain unclear. In the present study, we found that CTSB expression was abnormally elevated in the hippocampus of 3×Tg mice and was regulated by miR-96-5p.

Aryl-Diazafluoren(on)es for Organic Optoelectronics: Toward Air-Stable N-type OFETs and Gas Sensors.

While fluorene-containing materials are widely used in organic optoelectronics as bright emitters and hole semiconductors, their diazafluorene analogues have been poorly explored, though their nitrogen atoms could result in electron transport and bring sensory abilities. Here, we report the synthesis, characterization, and detailed study of a series of 4,5-diazafluorene-derivatives with different donor/acceptor substituents and organic semiconductors based on these molecules. The crystal structures of all the materials were solved by X-ray diffraction, indicating the presence of extensive π-stacking and anisotropic charge-transfer pathways.

Computer-aided design of enzyme-polyelectrolyte complexes for mycotoxin degradation at acidic pH.

The growing efforts towards preparation and investigation of supramolecular complexes formed by proteins and other polymers are determined by their promising biochemical and physical properties. In the current work, interaction of 6 enzymes, catalyzing transformation of various mycotoxins, with 8 polymers of variable structure and length was simulated to predict the best possible complex composition. The localization and portion of occupied areas on the enzyme surface varied widely, thus allowing the selection of those enzyme-polymer pairs for maximal retention of enzyme activity.

Bio-based materials regulating interfacial behavior of multiphase systems during CO geological utilization and storage: A review.

CO₂ geological utilization and storage involve complex multiphase interfacial behaviors that significantly influence the overall efficiency. Recently, bio-based materials have attracted increasing attention as promising candidates for interfacial regulation owing to their structural diversity, abundance, and environmental compatibility. This review summarizes recent advances in utilizing biomass-derived materials to regulate interfacial behaviors in subsurface multiphase systems.

Enabling Fluorescence Lifetime Imaging Multiplexing Using UnaG through Its Modification with Canonical and Noncanonical Amino Acids.

Fluorogen-activating proteins are powerful molecular tools for microscopy, including functional imaging. These proteins serve as an alternative to GFP-like proteins, as they do not require oxygen for chromophore maturation. However, the restricted selectivity of proteins to chromophores, combined with the limited number of spectral channels of conventional fluorescent microscopes, hinders the development of multicolor synthetic dyes.

Specificity and mechanism of tRNA cleavage by the AriB Toprim nuclease of the PARIS bacterial immune system.

Transfer RNA (tRNA) molecules have been recently recognized as widespread targets of bacterial immune systems. Translation inhibition through tRNA cleavage or modification inhibits phage propagation, thereby protecting the bacterial population. To counteract this, some viruses encode their own tRNA molecules, allowing infection to take place.

5-(4-Hydroxy-1,3-dioxoisoindolin-2-yl)-2,3-dihydrophthalazine-1,4-dione (HDDD) as effective substrate in HRP-catalyzed enhanced chemiluminescence reaction.

By modifying the amino group of luminol, 5-(4-hydroxy-1,3-dioxoisoindolin-2-yl)-2,3-dihydrophthalazine-1,4-dione (HDDD) was synthesized. Using a combination of full factorial design and "one-variable-time" method, favorable conditions for the generation of HDDD-dependent chemiluminescence were determined. It was shown that replacing luminol with HDDD in the HRP-C-catalyzed enhanced chemiluminescence reaction increased the luminescence intensity.

[On the 60th anniversary of the P. Lauren's classification of histological types of gastric cancer].

The epidemiological data on the incidence of gastric cancer and its mortality make it a challenge for oncologists to find new and improve existing diagnostic methods and therapies. Despite the active change of modern realities in the practice of pathomorphologist for 60 years remains unchanged authority of the P.Laurén classification of histological main types.

[Correlation of tumor budding with DNA mismatch repair system and PD-L1-status in gastric cancer].

Objective: To detect the presence or absence of correlations between the degree of tumor budding (TB) and pMMR/dMMR (proficient Mismatch Repair System/deficient Mismatch Repair System) and PD-L1 status in gastric cancer (GC).

Material And Methods: Surgical material from 173 patients with verified gastric cancer of the tubular histological subtype, where the invasive edge of the carcinoma was examined, tumor budding were identified and counted by three methods: H. Ueno, L.

Aliphatic saturated sulfones C8-C10 as new electrolyte solvents for Li batteries.

The search for new electrolytes (including solvents and salts) is essential for the development of lithium batteries. The sulfone family of solvents has gained significant attention due to their high electrochemical and thermal stability. In this study, we have explored the potential application of aliphatic non-cyclic sulfones with C8 to C10 carbon chains as electrolyte solvents for lithium batteries ((i-CH)SO, (i-CH)SO, and (i-CH) (i-CH)SO).

Prolonged intermittent home video-EEG monitoring for drug-resistant epilepsy: the cost-availability model.

Video-EEG monitoring (VEM) is an obligatory step in drug-resistant epilepsy (DRE) management. The common way of VEM is in-hospital VEM (IVEM), which is limited by the need to admit the patient to the epilepsy monitoring unit. Prolonged intermittent home VEM (PIHVEM) can be a more available alternative.

The Indo-European Cognate Relationships dataset.

The Indo-European Cognate Relationships (IE-CoR) dataset is an open-access relational dataset showing how related, inherited words ('cognates') pattern across 160 languages of the Indo-European family. IE-CoR is intended as a benchmark dataset for computational research into the evolution of the Indo-European languages. It is structured around 170 reference meanings in core lexicon, and contains 25731 lexeme entries, analysed into 4981 cognate sets.

Cortical responses to tactile imagery: a high-density EEG study of the μ-rhythm event-related desynchronization and somatosensory evoked potentials.

Tactile imagery (TI) engages somatosensory cortices in both hemispheres, along with widespread brain regions associated with the imagery process itself. Actively simulating touch can influence the processing of actual tactile stimuli, as reflected by modulations in somatosensory evoked potentials (SEPs) components. This study uses high-density electroencephalography (EEG) and sLORETA-based source localization to analyse cortical sources of SEPs components susceptible to active skin sensations imagery.

ZnO/Ag Nanostructures for Surface-Enhanced Raman Spectroscopy: Effect of Wedge Microcavity.

Zinc oxide (ZnO) nanostructures with deposited silver (Ag) nanoparticles (NPs) exhibit exceptional opportunities for highly sensitive molecular diagnostics by means of the Surface-Enhanced Raman Scattering (SERS). Here we use the well known method of the hydrothermal synthesis of arrays of ZnO nanorods (NRs), followed with deposition of Ag-NPs by facile photochemical reduction under UV-light illumination to obtain ZnO-NRs/Ag-NPs hybrid structures with superior SERS activity. SERS spectra of a probe analyte, i.

Taxonomic and metabolic diversity of microbial communities in a thermal water stream in Uzbekistan and proposal of two new classes of uncultivated bacteria, Desulfocorpusculia class. nov. and Tepidihabitantia class. nov., named following the rules of SeqCode.

Thermal ecosystems in Uzbekistan remain poorly characterized, particularly through culture-independent approaches. In this study, we performed 16S rRNA gene metabarcoding and metagenomic sequencing of microbial communities from a hot stream formed by the discharge of thermal artesian groundwater in the Navoiy region. The taxonomic composition of microbial communities varied with temperature and sample type, with the phylum Chloroflexota abundant in most samples.

3D-printable bio-sourced nanocomposite hydrogels based on two polysaccharide components: hydroxypropyl guar macromolecules and cellulose nanocrystals.

Hydrogels are soft and wet materials which require enhanced mechanical properties and toughness. For this aim, double-network hydrogels were prepared from soft network of covalently crosslinked hydroxypropyl guar and hard self-assembled network of carboxymethylated cellulose nanocrystals (CNCs) reversibly crosslinked by calcium ions. The gels exhibited a dramatic enhancement of mechanical strength and toughness with increasing content of CNCs and demonstrated remarkable fatigue resistance.

The Use of Specialized Neuropsychological Training for the Rehabilitation of Patients with Neglect Syndrome.

Background: Currently, insufficient attention is being paid to methods of rehabilitation of patients with neglect syndrome. It is necessary to create an effective way to overcome this condition.

Objective: After we developed and tested a specialized rehabilitation training program for patients with neglect syndrome, we sought to verify that the designed program would have a positive impact on the indicators of visuospatial search in these patients, in contrast to a control group.

The Effects of Emotional States and World Assumptions on Moral Disengagement in Adolescents from Combat Zones.

Background: Extreme events, including warfare, lead to transformations in moral norms and the heightened intensity of moral disengagement mechanisms, which may be prolonged or become irreversible. Research to identify the factors that reduce the frequency of moral disengagement mechanisms among adolescents can lead to understanding how to prevent and decrease the intensity of destructive behavior.

Objective: To identify the emotional states and fundamental belief systems that correlate with the intensity of moral disengagement in adolescents from combat zones, compared to peers in a control group.

Expression Interplay Between Cathepsin B and Its Natural Inhibitor Stefin A in Cancer and Embryonic Cell Lines.

Cathepsin B (CTSB) is a lysosomal protease that also operates outside the acidic environment of lysosomes. In healthy cells, CTSB plays a crucial role in processes such as apoptosis, autophagy, and the maintenance of cellular homeostasis. However, in cancer, it contributes significantly to disease progression by promoting invasion and metastasis.

The fluorescence asymmetry ratio as an optical index of antioxidant activity of RP-HPLC fractions of fulvic acids.

Fulvic acids (FAs) have recently gained substantial attention as potential biostimulants within the category of complex carbon-based plant stimulants. However neither preparative techniques for isolation of highly active FA components nor quality control demands are formulated yet for FA-based biostimulants. The study aims to evaluate antioxidant capacities (AOCs) of the FA fractions obtained from the commercial FA material with a use of the preparative RP-HPLC technique and to establish relationships between the AOC values, molecular composition and optical properties in search of the reliable quality control parameters indicating enhanced AOC values of FA.

Association between Human Leukocyte Antigen Alleles and Endocrine Disorders in a Cohort of 895 Patients from Russian Clinical Population.

Endocrine disorders represent a serious public health problem and frequently can be caused by genetic factors or their combination with environmental and lifestyle factors. Assessment of relevant genetic factors is important to estimate the risk of endocrine pathologies in an individual before their manifestation. Identification of genetic variations in proteins of the major histocompatibility complex is important with regard to the autoimmune nature of many endocrine pathologies, including type 1 diabetes.

Ribosome in Baker's Yeast Mitochondria are Heterogeneous.

Ribosomes are macromolecular machines of conveyor type, which move along the mRNA from triplet to triplet and polymerize cognate amino acids. They are regarded as uniform entities with constant molecular composition bearing no regulatory capacity. However, their ability to interact with multiple proteins involved in translation suggests existence of specialized ribosomes dedicated to biosynthesis of particular proteins.