Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/hepr.13997 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dynamic Synthesis of Multi-Modal Representations for CITE-seq Data Integration and Analysis.
Adv Sci (Weinh)
September 2025
School of Artificial Intelligence, Jilin University, Changchun, 130012, China.
Single-cell multi-omics technologies are pivotal for deciphering the complexities of biological systems, with Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq) emerging as a particularly valuable approach. The dual-modality capability makes CITE-seq particularly advantageous for dissecting cellular heterogeneity and understanding the dynamic interplay between transcriptomic and proteomic landscapes. However, existing computational models for integrating these two modalities often struggle to capture the complex, non-linear interactions between RNA and antibody-derived tags (ADTs), and are computationally intensive.
View Article and Find Full Text PDFClinical Comparison of Decipher 1.0 and 1.1 for Localized Prostate Cancer: Results in Prostatectomy and Active Surveillance Patients.
Eur Urol Oncol
September 2025
Department of Urology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA; Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA. Electronic address:
Decipher is a 22-gene genomic risk classifier that utilizes a whole-transcriptome microarray assay to provide a score ranging from 0 to 1. Recently, the individual gene scores that defined Decipher v1.0 were reweighted to define updated Decipher v1.
View Article and Find Full Text PDFCalprotectin protects in coculture with by attenuating quorum sensing and decreasing the production of pseudomonal antimicrobials.
mSystems
September 2025
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
and cause debilitating polymicrobial infections in diverse patient populations. Studies of these bacterial pathogens in coculture have shown that environmental variables, including Fe availability and the host-defense protein calprotectin (CP), impact coculture dynamics. To decipher how CP modulates interactions between and , we employed dual-species RNA-seq to examine the transcriptional responses of both pathogens in coculture to CP treatment and metal depletion.
View Article and Find Full Text PDFCrosstalk between noncoding RNAs and autophagy in renal cell carcinoma: Deciphering molecular pathways and therapeutic prospects.
Cancer Cell Int
September 2025
Nephrology and Urology Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Renal cell carcinoma (RCC) is one of the most common and aggressive forms of kidney cancer, accounting for over 90% of cases. Despite advances in diagnosis and treatment, RCC is often detected at advanced stages and demonstrates poor response to traditional therapies such as chemotherapy, radiotherapy, and hormonal treatment. Consequently, novel molecular targets are urgently needed.
View Article and Find Full Text PDFTranscriptome dynamics and allele-specific regulation underlie wheat heterosis at the anthesis and grain-filling stages.
BMC Genomics
September 2025
Wheat Research Center, Henan Institute of Science and Technology, Xinxiang, 453000, China.
Background: As wheat is a globally important staple crop, the molecular regulatory network underlying heterosis in wheat remains incompletely understood. The flag leaf is the primary source of photoassimilates during grain filling and plays a crucial role in yield formation. However, the genetic mechanisms linking flag leaf development to heterosis are still unclear.
View Article and Find Full Text PDF