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Article Abstract
Background: is a cyanobacteria species containing various bioactive compounds. is a known source of nutrients in some traditional diets. Different activities have been reported for various extracts of .
Objectives: In this study, the polysaccharide content of culture media and biomass extract of one species of was partially purified, and its analgesic and anti-inflammatory effects were evaluated.
Methods: PCST5 was cultured in a sterile Zarouk medium at 27°C and 16/8h of light/ dark exposure cycle for 25 days. Then, the polysaccharide content of biomass and cell-free culture medium samples (BPSs and CFPSs, respectively) was partially purified. The analgesic and anti-inflammatory effects were evaluated using animal models.
Results: gene analysis confirmed that the organism was genetically similar to . The CFPSs (30 and 100 mg/kg) and BPSs (30 mg/kg) significantly reduced pain-related behaviors in rats. Similarly, all samples could significantly reduce carrageenan-induced paw inflammation volume compared with the control group. Our results suggest 's polysaccharide fractions (CFPSs and BPSs) had significant analgesic and anti-inflammatory effects.
Conclusions: Since is a readily available source of bioactive compounds, finding such potent anti-inflammatory and anti-nociceptive compounds can provide promising leads for novel drug development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10728851 | PMC |
| http://dx.doi.org/10.5812/ijpr-136661 | DOI Listing |
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