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Background: Kidney and ureter stones are the third pathologies in urological diseases. Less invasive treatments such as transureteral lithotripsy and extracorporeal shock wave lithotripsy are used to treat ureteral stones. Data mining has provided the possibility of improving decision-making in choosing the optimal treatment. In this paper predictive models for the detection of ureter stone treatment (first model) and its outcome (second model) is developed based on the patient's demographic, clinical, and laboratory factors.
Methods And Material: In this cross-sectional study a questionnaire was used to identify the most effective features in the predictive models, and Information on 440 patients was collected. The models were constructed using machine learning techniques (Multilayer perceptron, Classification, and regression tree, k-nearest neighbors, Support vector machine, Naïve Bayes classifier, Random Forest, and AdaBoost) in the Bigpro1 analytical system.
Results: Among the Holdout and K-fold cross-validation methods used, the Holdout method showed better performance. From the data-based balancing methods used in the second model, the Synthetic Minority oversampling technique showed better performance. Also, the AdaBoost algorithm had the best performance. In this algorithm, accuracy, sensitivity, specificity, precision, F- measure, and Area under the carve in the first model were 89%, 87%, 91%, 90%, 89%, and 94% respectively, and in the second model were 81%, 81%, 82%, 84%, 82%, and 85% respectively.
Conclusions: The results were promising and showed that the data mining techniques could be a powerful assistant for urologists to predict a surgical outcome and also to choose an appropriate surgical treatment for removing ureter stones.
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http://dx.doi.org/10.4103/abr.abr_121_23 | DOI Listing |
Environ Monit Assess
September 2025
Department of Civil Engineering, Faculty of Engineering, Karpagam Academy of Higher Education, Pollachi Main Road, Eachanari Post, Coimbatore, Tamil Nadu, 641021, India.
Synthetic dyes, such as Congo red (CR), pose serious threats to human health and aquatic ecosystems because of their carcinogenicity and resistance to degradation, necessitating the development of efficient and eco-friendly remediation strategies. In this study, silver nanoparticles (AgNPs) were synthesized via a green method using Ocimum sanctum (holy basil) leaf extract and applied for CR dye removal from aqueous solutions. The adsorption process was optimized using response surface methodology (RSM) based on Box-Behnken design (BBD), evaluating the influence of key parameters including pH, AgNP dosage, initial dye concentration, contact time, and temperature.
View Article and Find Full Text PDFStem Cell Rev Rep
September 2025
Department of Medical Genetics and Prenatal Diagnostics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
The emergence of organoid models has significantly bridged the gap between traditional cell cultures/animal models and authentic human disease states, particularly for genetic disorders, where their inherent genetic fidelity enables more biologically relevant research directions and enhances translational validity. This review systematically analyzes established organoid models of genetic diseases across organs (e.g.
View Article and Find Full Text PDFOncogene
September 2025
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Pancreatic cancer is a highly aggressive malignancy with a dismal prognosis, characterized by a complex tumor microenvironment that promotes immunosuppression and limits the efficacy of immune checkpoint blockade (ICB) therapy. Fibroblast activation protein (FAP) is overexpressed in the tumor stroma and represents a promising target for therapeutic intervention. Here, we developed a novel antibody-drug conjugate (ADC) targeting FAP, and investigated its anti-tumor activity and ability to enhance ICB efficacy in pancreatic cancer.
View Article and Find Full Text PDFJ Chem Inf Model
September 2025
School of Medicine and Warshel Institute for Computational Biology, The Chinese University of Hong Kong─Shenzhen, Shenzhen, Guangdong 518172, China.
Argonaute (Ago) is a DNA-guided programmable endonuclease with emerging applications in genome engineering, yet the rate-determining dynamic mechanisms governing its transition from guide-target hybridization to catalytic activation remain unresolved. Here, we employ molecular dynamics simulations and the Traveling-salesman-based Automated Path Searching (TAPS) approach to dissect the target DNA recognition in the middle region (nt 9-12) of Ago. We designed two paths to tackle this problem: one assumed that coordination of the target DNA backbone occurs before base-pairing between the target and guide DNA; the other hypothesized a concerted transition without preferred order between backbone-coordination and base-pairing.
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