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There is a common need in the advancement of optical diagnostic techniques to increase the dimensionality of measurements. For example, point measurements could be improved to multi-point, line, planar, volumetric, or time-resolved volumetric measurements. In this work, a unique optical element is presented to enable multi-dimensional measurements, namely, an array of glass wedges. A light source is passed through the wedges, and different portions of the illumination are refracted by different amounts depending on the glass wedge angle. Subsequent optics can be used to focus the light to multiple points, lines, or planes. Basic characterization of a glass wedge array is presented. Additional wedge-array configurations are discussed, including the use of a periodic intensity mask for multi-planar measurements via structured illumination. The utility of this optical element is briefly demonstrated in (a) multi-planar flame particulate measurements, (b) multi-point femtosecond-laser electronic excitation tagging for flow velocimetry, and (c) multi-line nitric oxide molecular tagging velocimetry in a hypersonic shock-tunnel. One significant advantage of this optical component is its compatibility with high-energy laser sources, which may be a limiting factor with other beam-splitting or beam-forming elements such as some diffractive optics. Additionally, an array of glass wedges is simple and easily customizable compared to other methods for forming multiple closely spaced illumination patterns. Suggestions for further development and applications are discussed.
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http://dx.doi.org/10.1364/AO.504117 | DOI Listing |
Front Oncol
July 2025
Department of Pathology, 920th Hospital of the Joint Logistics Support Force of Chinese People's Liberation Army, Kunming, Yunnan, China.
Background: Bronchiolar adenoma/ciliated muconodular papillary tumor (BA/CMPT) is a rare benign pulmonary tumor from the bronchiolar epithelium. Histologically, it features a continuous basal cell layer and luminal cells. Its resemblance to invasive mucinous adenocarcinoma (IMA) and acinar adenocarcinoma complicates intraoperative frozen section diagnosis.
View Article and Find Full Text PDFWe experienced two cases of lung cancer in teenagers. Case 1 involved a 17-year-old never-smoking girl with no medical history. Chest computed tomography revealed a 9 × 7 mm ground-glass nodule in the left lung.
View Article and Find Full Text PDFAnn Am Thorac Soc
July 2025
Mayo Clinic, Rochester, Minnesota, United States;
Rationale And Objectives: Pulmonary Hypertension (PH) is associated with significant morbidity and mortality. Ground glass opacities (GGOs) are common in Group 1 PH, but their clinical significance is unclear. We sought to characterise the clinical features and outcomes of Group 1 PH patients with and without GGOs in the PVDOMICS study, a prospective multicentre cohort study aimed at deep phenotyping PH.
View Article and Find Full Text PDFClin Oral Investig
July 2025
Istanbul University- Cerrahpasa, Faculty of Dentistry, Department of Restorative Dentistry, Istanbul, Turkey.
Objectives: Recently, single-shade universal composite resins have been introduced to the market to simplify restorative procedures. The inorganic structures of dental composites may influence several properties, including radiopacity. Radiopacity plays a crucial role in clinical dentistry as it enables the detection of recurrent caries, marginal defects, and restoration overhangs through radiographic examination.
View Article and Find Full Text PDFJ Clin Med
June 2025
Department of Medical Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95123 Catania, Italy.
: This study aims to distinguish radiological differences between primary idiopathic Usual Interstitial Pneumonia (UIP) and secondary UIP patterns : This retrospective study included patients with HRCT findings consistent with a UIP pattern. Final diagnoses were established via multidisciplinary discussion and classified as primary UIP/IPF or secondary UIP, following the 2022 ATS/ERS/JRS/ALAT guidelines. An expert thoracic radiologist (>10 years of experience), blinded to clinical data, reviewed the earliest available HRCT assessing key imaging features: honeycombing (micro-, macro- or exuberant), fibrosis distribution (symmetry, anterior-upper lobe sign, etc.
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