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A thermostable, safe, and effective NDV GVII recombinant vaccine was generated.Fusion gene replacement with GVII did not affect GI K148/08 virus thermostability.Strain rK148/GVII-F provided adequate protection against a lethal NDV challenge.Oropharyngeal shedding was significantly reduced on post-challenge days 5 and 7.
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http://dx.doi.org/10.1080/03079457.2023.2263395 | DOI Listing |
Chin Med
July 2025
Department of Microbiology, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.
Background: Aster tataricus, a perennial terrestrial herb with a rich history of use in traditional medicine, is renowned for its therapeutic properties. However, despite the widespread use of Aster tataricus, its antiviral efficacy and mode of action against viruses have not yet been studied. Here, we demonstrated that Aster tataricus extract (ATE) has antiviral effects and an underlying mechanism of action both in vitro and in vivo.
View Article and Find Full Text PDFFront Vet Sci
April 2025
Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
The widespread H5 clade 2.3.4.
View Article and Find Full Text PDFFront Oncol
April 2025
Center of Laboratory Animal, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Background: Newcastle disease virus (NDV) has emerged as a tumor-lysing agent in a variety of cancers. Previous studies have shown that NDV has cytolytic activity in gliomas; however, the underlying mechanisms have not been fully elucidated.
Methods: Comparing the glioma cells LN229 controlled group with the infected group of NDV rLa Sota-GFP strain, we strive to observe the changes in the genome and protein levels as well as the activation of the signalling pathways before and after the infection at the cellular level and at the level of the genes in the transcriptome, to study the molecular mechanism of necroptosis of the NDV-infected lethal LN229.
Npj Viruses
August 2024
Center for Translational Medicine, Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, University of Montana, Missoula, MT, USA.
Many different platforms have been used to develop highly protective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans. However, protection has eroded over time due to the emergence of antigenically diverse viral variants, especially the Omicron subvariants. One successful platform for the generation of SARS-CoV-2 vaccines are recombinant spike protein vaccines, of which two are licensed in the United States and Europe.
View Article and Find Full Text PDFPoult Sci
June 2025
Department of Basic Sciences, College of Veterinary Medicine, University of Sulaimani, New Sulaimani, Street 27, Sulaymaniyah 46001, Kurdistan Region, Iraq. Electronic address:
Newcastle disease (ND), caused by the Newcastle disease virus (NDV), has no approved therapy, and vaccination often fails to eradicate infection in endemic areas. In this study, the antiviral effect of remdesivir was tested against experimental ND in broilers. First, the NDV was isolated and identified from an outbreak in a broiler farm in Sulaymaniyah, Iraq.
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