Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Discogenic back pain, a subset of chronic back pain, is caused by intervertebral disc (IVD) degeneration, and imparts a notable socioeconomic health burden on the population. However, degeneration by itself does not necessarily imply discogenic pain. In this review, we highlight the existing literature on the pathophysiology of discogenic back pain, focusing on the biomechanical and biochemical steps that lead to pain in the setting of IVD degeneration. Though the pathophysiology is incompletely characterized, the current evidence favors a framework where degeneration leads to IVD inflammation, and subsequent immune milieu recruitment. Chronic inflammation serves as a basis of penetrating neovascularization and neoinnervation into the IVD. Hence, nociceptive sensitization emerges, which manifests as discogenic back pain. Recent studies also highlight the complimentary roles of low virulence infections and central nervous system (CNS) metabolic state alteration. Targeted therapies that seek to disrupt inflammation, angiogenesis, and neurogenic pathways are being investigated. Regenerative therapy in the form of gene therapy and cell-based therapy are also being explored.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647359 | PMC |
| http://dx.doi.org/10.3390/jcm12216907 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Human Progenitor Cell-Based Tissue Engineered Intervertebral Disc.
Tissue Eng Part A
September 2025
Department of Orthopaedic Surgery, McKay Orthopaedic Research Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Cell and tissue engineering therapies provide promise for regenerating damaged intervertebral disc (IVD) tissue and resolving the low back pain that often accompanies it. However, these treatments remain experimental and unavailable for patients. Furthermore, the large body of work characterizing and utilizing mesenchymal stromal cells (MSCs) for these applications has, unfortunately, not resulted in any FDA-approved spinal therapies.
View Article and Find Full Text PDFMechanism of lidocaine-induced ROS generation triggering DNA double-strand breaks and promoting intervertebral disc cell senescence via the MYC-DUSP1-P53 axis.
Free Radic Biol Med
August 2025
Department of Orthopaedics, The Second Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, China. Electronic address:
Discogenic lower back pain (DLBP) is a prevalent lumbar disorder. Functional Anesthetic Discography (FAD) is the primary diagnostic method for DLBP, with a high positivity rate. However, the mechanism by which lidocaine, a local anesthetic commonly used in FAD, induces damage to intervertebral disc cells remains unclear.
View Article and Find Full Text PDFPlatelet-rich plasma for the treatment of discogenic low back pain: a prospective randomized controlled trial.
Front Pain Res (Lausanne)
August 2025
Department of Rehabilitation and Pain, Zigong Fourth People's Hospital, Zigong, Sichuan, China.
Objective: This study aimed to compare the therapeutic effect of PRP and methylene blue injection in patients with discogenic low back pain.
Methods: A total of 40 patients with discogenic low back pain were randomly divided into two groups, with 20 patients in group A receiving platelet-rich plasma injections and 20 patients in group B receiving methylene blue injections. Visual analog scale (VAS) scores, Japanese Orthopaedic Association (JOA) scores, Pfirrmann grades, and MRI apparent diffusion coefficients (ADCs) were recorded in both groups before the injections and 6 months after the injections.
Effect of femoral greater trochanter compression on chair-sitting difficulty due to sacroiliac joint disorder: A clinical and numerical study.
Clin Biomech (Bristol)
August 2025
Japan Sacroiliac Joint and Low Back Pain Center, Japan Community Healthcare Organization Sendai Hospital, Sendai, Japan; Department of Orthopedic Surgery, Japan Community Healthcare Organization Sendai Hospital, Sendai, Japan.
Background: Sacroiliac joint disorder commonly causes low back pain, aggravated by sitting, thereby affecting daily activities. Although clinical observations suggest that compression of the greater trochanter may improve sacroiliac joint pain while sitting, the biomechanical effects remain unknown. We investigated their clinical effects and validated them through in silico analysis.
View Article and Find Full Text PDF14. Discogenic Low Back Pain.
Pain Pract
September 2025
Department of Anesthesiology, Pain and Palliative Medicine, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Introduction: Discogenic low back pain can be severely disabling, clinically challenging to diagnose, and expensive to treat. Disc degeneration is characterized by disc dehydration, which diminishes the ability of the disc to distribute pressure, making it more susceptible to damage, and leading to annular tears, fissures, and a higher incidence of herniation. Furthermore, the abnormal annular in-growth of nerves and inflammation of the disc increase the number and sensitivity of nociceptors, leading to chronic discogenic low back pain (CDLBP).
View Article and Find Full Text PDF